Netrin-integrin signaling in epithelial morphogenesis, axon guidance and vascular patterning Journal Article
| Authors: | Nikolopoulos, S. N.; Giancotti, F. G. |
| Article Title: | Netrin-integrin signaling in epithelial morphogenesis, axon guidance and vascular patterning |
| Abstract: | Netrins and their classical receptors - DCC and neogenin - play key roles in neuronal guidance. Recent developments identify new roles for netrins in epithelial and vascular morphogenesis. Netrins accomplish these effects, at least in part, through binding to integrins and/or activating integrin-associated kinases such as FAK and Fyn. Here we discuss these recent findings and propose that integrins and classical netrin receptors cooperate to regulate multiple aspects of development. ©2005 Landes Bioscience. |
| Keywords: | signal transduction; mitogen activated protein kinase; protein expression; unclassified drug; review; nonhuman; cell proliferation; cytology; animals; mice; models, biological; signaling; protein binding; morphogenesis; cell differentiation; nerve growth factors; neurons; enzyme activation; angiogenesis; phosphatidylinositol 3 kinase; cancer invasion; nerve fiber; tumor suppressor proteins; cell migration; cell movement; blood vessel; ligands; binding sites; receptor; epithelium; branching morphogenesis; neovascularization, physiologic; cell adhesion; nerve cell; cell motility; body patterning; integrin; rho guanine nucleotide binding protein; axons; oligomerization; laminin; integrins; focal adhesion protein-tyrosine kinases; phospholipase c gamma; receptors, cell surface; collagen type 4; growth cone; proto-oncogene proteins c-fyn; cell budding; axon guidance; epithelial morphogenesis; α3β1; α6β4; netrin; integrin receptor; netrin receptor |
| Journal Title: | Cell Cycle |
| Volume: | 4 |
| Issue: | 3 |
| ISSN: | 1538-4101 |
| Publisher: | Taylor & Francis Inc. |
| Date Published: | 2005-03-01 |
| Start Page: | e131 |
| End Page: | e135 |
| Language: | English |
| PUBMED: | 15725728 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 28" - "Export Date: 24 October 2012" - "Source: Scopus" |
