Integrin signaling: Specificity and control of cell survival and cell cycle progression Journal Article
| Author: | Giancotti, F. G. |
| Article Title: | Integrin signaling: Specificity and control of cell survival and cell cycle progression |
| Abstract: | Integrin-mediated adhesion to the extracellular matrix plays an important role in regulating cell survival and proliferation. There is now increasing evidence that integrins activate shared as well as subgroup-specific signaling pathways. The signals from these adhesion receptors are integrated with those originating from growth factor and cytokine receptors in order to organize the cytoskeleton, stimulate mitogen-activated protein kinase cascades, and regulate immediate early gene expression. The repertoire of integrins and composition of the extracellular matrix appear to dictate whether a cell will survive, proliferate or exit the cell cycle and differentiate in response to soluble factors. |
| Keywords: | signal transduction; mitogen activated protein kinase; review; nonhuman; cell proliferation; animals; cell survival; cell cycle; apoptosis; cell differentiation; enzyme activation; extracellular matrix; gene expression regulation; membrane protein; cell migration; fibroblasts; epithelial cells; ras protein; cell adhesion; guanine nucleotide binding protein; protein kinase; focal adhesion kinase; integrin; integrins; cytokine receptor; guanosine triphosphatase; growth factor receptor; membrane enzyme; hemidesmosome; human; priority journal; immediate early gene |
| Journal Title: | Current Opinion in Cell Biology |
| Volume: | 9 |
| Issue: | 5 |
| ISSN: | 0955-0674 |
| Publisher: | Elsevier Inc. |
| Date Published: | 1997-10-01 |
| Start Page: | 691 |
| End Page: | 700 |
| Language: | English |
| DOI: | 10.1016/s0955-0674(97)80123-8 |
| PUBMED: | 9330873 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 17 March 2017 -- Source: Scopus |
