Positional control of cell fate through joint integrin/receptor protein kinase signaling Journal Article


Authors: Giancotti, F. G.; Tarone, G.
Article Title: Positional control of cell fate through joint integrin/receptor protein kinase signaling
Abstract: Cells adhere to the extracellular matrix throughout most of their lifetime. This close, intimate contact with the matrix exerts an extraordinary control on the behavior of cells, determining whether they move or stay put, proliferate or remain quiescent, and even live or die. Attachment to the matrix not only enables cells to respond to soluble growth factors and cytokines but also determines the nature of the response. The integrins are a large family of receptors that attach cells to the matrix, organize their cytoskeleton, and cooperate with receptor protein tyrosine kinases to regulate cell fate. Research on integrin signaling is beginning to explain the complex and specific effects that the extracellular matrix exerts on cells.
Keywords: signal transduction; mitogen activated protein kinase; unclassified drug; nonhuman; conference paper; protein function; cell proliferation; protein analysis; animals; cell death; cell survival; cell cycle; cell division; cell function; stress activated protein kinase; cell fate; extracellular matrix; cytokine; regulatory mechanism; receptor protein-tyrosine kinases; protein family; growth factor; cell adhesion; cytoskeleton; protein kinase; cell activity; integrin; integrins; lifespan; cyclin d; cell contact; tetraspanin; growth factor receptor; humans; human; priority journal; receptor protein kinase
Journal Title: Annual Review of Cell and Developmental Biology
Volume: 19
ISSN: 1081-0706
Publisher: Annual Reviews  
Date Published: 2003-11-01
Start Page: 173
End Page: 206
Language: English
DOI: 10.1146/annurev.cellbio.19.031103.133334
PUBMED: 14570568
PROVIDER: scopus
DOI/URL:
Notes: Export Date: 25 September 2014 -- Source: Scopus
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