Integrin signaling Journal Article
| Authors: | Giancotti, F. G.; Ruoslahti, E. |
| Article Title: | Integrin signaling |
| Abstract: | Cells reside in a protein network, the extracellular matrix (ECM), which they secrete and mold into the intercellular space. The ECM exerts profound control over cells. The effects of the matrix are primarily mediated by integrins, a family of cell surface receptors that attach cells to the matrix and mediate mechanical and chemical signals from it. These signals regulate the activities of cytoplasmic kinases, growth factor receptors, and ion channels and control the organization of the intracellular actin cytoskeleton. Many integrin signals converge on cell cycle regulation, directing cells to live or die, to proliferate, or to exit the cell cycle and differentiate. |
| Keywords: | signal transduction; review; cell proliferation; animals; cell cycle; cell division; apoptosis; protein kinases; cell differentiation; enzyme activity; extracellular matrix; cell size; cytoskeleton; integrin; receptor binding; integrins; cell secretion; cell physiology; ion channel; humans; priority journal; intercellular space |
| Journal Title: | Science |
| Volume: | 285 |
| Issue: | 5430 |
| ISSN: | 0036-8075 |
| Publisher: | American Association for the Advancement of Science |
| Date Published: | 1999-08-13 |
| Start Page: | 1028 |
| End Page: | 1032 |
| Language: | English |
| DOI: | 10.1126/science.285.5430.1028 |
| PUBMED: | 10446041 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Export Date: 16 August 2016 -- Source: Scopus |
