RGMa and RGMb expression pattern during chicken development suggest unexpected roles for these repulsive guidance molecules in notochord formation, somitogenesis, and myogenesis Journal Article
| Authors: | Jorge, E. C.; Ahmed, M. U.; Bothe, I.; Coutinho, L. L.; Dietrich, S. |
| Article Title: | RGMa and RGMb expression pattern during chicken development suggest unexpected roles for these repulsive guidance molecules in notochord formation, somitogenesis, and myogenesis |
| Abstract: | Background: Repulsive guidance molecules (RGM) are high-affinity ligands for the Netrin receptor Neogenin, and they are crucial for nervous system development including neural tube closure; neuronal and neural crest cell differentiation and axon guidance. Recent studies implicated RGM molecules in bone morphogenetic protein signaling, which regulates a variety of developmental processes. Moreover, a role for RGMc in iron metabolism has been established. This suggests that RGM molecules may play important roles in non-neural tissues. Results: To explore which tissues and processed may be regulated by RGM molecules, we systematically investigated the expression of RGMa and RGMb, the only RGM molecules currently known for avians, in the chicken embryo. Conclusions: Our study suggests so far unknown roles of RGM molecules in notochord, somite and skeletal muscle development. © 2012 Wiley Periodicals, Inc. |
| Keywords: | signal transduction; protein expression; unclassified drug; nonhuman; protein function; embryo; developmental biology; cell differentiation; in vitro study; membrane protein; iron; neurogenesis; biogenesis; organogenesis; muscle development; neural plate; somitogenesis; notochord; chicken; neurulation; somite; dermomyotome; dorsal root ganglia; dragon; myotome; pharyngeal ectoderm; rgma; rgmb; repulsive guidance molecule a protein; repulsive guidance molecule b protein; iron metabolism |
| Journal Title: | Developmental Dynamics |
| Volume: | 241 |
| Issue: | 12 |
| ISSN: | 1058-8388 |
| Publisher: | Wiley Periodicals, Inc |
| Date Published: | 2012-12-01 |
| Start Page: | 1886 |
| End Page: | 1900 |
| Language: | English |
| DOI: | 10.1002/dvdy.23889 |
| PROVIDER: | scopus |
| PUBMED: | 23073896 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 2 January 2013" - "CODEN: DEDYE" - "Source: Scopus" |
