Altered expression of DNA double-strand repair genes Ku70 and Ku80 in carcinomas of the oral cavity Journal Article
| Authors: | Korabiowska, M.; Voltmann, J.; Hönig, J. F.; Bortkiewicz, P.; König, F.; Cordon-Cardo, C.; Jenckel, F.; Ambrosch, P.; Fischer, G. |
| Article Title: | Altered expression of DNA double-strand repair genes Ku70 and Ku80 in carcinomas of the oral cavity |
| Abstract: | The relevance of double-strand DNA repair genes has been demonstrated in several tumours. The main aim of this study was to analyse the expression of the heterodimers Ku70 and Ku80, building regulatory subunits of the DNA-dependent protein kinase in 40 oral carcinomas. Ku70 expression was found in 87.5% of grade 1 and grade 3 tumours and in 82.9% of grade 2 carcinomas. Ku80 presence was noted in 87.5% of grade 1 tumours, 82.9% of grade 2 tumours and in all grade 3 tumours. Ku70-positive cells were present in 90.5% of tumours without and in 80% of tumours with lymphatic metastases. A similar relationship was found for Ku80 expression. Additionally, the expression of Ku70 was highly significantly related to smoking habits. Our results demonstrated that defects of DNA double-strand repair genes play an important role in the tumour progression of oral carcinomas. |
| Keywords: | adult; clinical article; protein expression; aged; aged, 80 and over; middle aged; unclassified drug; dna-binding proteins; cigarette smoking; carcinoma, squamous cell; lymph node metastasis; lymphatic metastasis; neoplasm staging; cancer grading; dna repair; smoking; dna, neoplasm; tumor growth; ku antigen; mouth carcinoma; mouth neoplasms; oral cancer; dna dependent protein kinase; ku70; antigens, nuclear; ku80; protein ku80 |
| Journal Title: | Anticancer Research |
| Volume: | 26 |
| Issue: | 3A |
| ISSN: | 0250-7005 |
| Publisher: | International Institute of Anticancer Research |
| Date Published: | 2006-05-01 |
| Start Page: | 2101 |
| End Page: | 2105 |
| Language: | English |
| PUBMED: | 16827151 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 5" - "Export Date: 4 June 2012" - "CODEN: ANTRD" - "Source: Scopus" |
