Loss of Ku70/Ku80 expression occurs more frequently in hereditary than in sporadic colorectal tumors. Tissue microarray study Journal Article
| Authors: | Korabiowska, M.; Cordon-Cardo, C.; Schinagl, M.; Karaus, M.; Stachura, J.; Schulz, H.; Fischer, G. |
| Article Title: | Loss of Ku70/Ku80 expression occurs more frequently in hereditary than in sporadic colorectal tumors. Tissue microarray study |
| Abstract: | Ku70 and Ku80 proteins take part in the repairing of DNA double-strand breaks by their function as a regulatory subunit of the DNA-dependent protein kinase. In this study, expression of both genes was analyzed in colorectal carcinoma tissue arrays applying immunohistochemistry. Expression of both genes decreased along with pT stage. Significant differences in Ku70 and Ku80 expression were found between pT3 and pT4 as well as between pT2 and pT3 tumors, respectively. Loss of Ku70/Ku80 expression was more frequently observed in hereditary than in sporadic tumors. We conclude that expression of Ku70/Ku80 genes is down-regulated in colorectal carcinoma and that defects of these genes are more frequently observed in hereditary than in sporadic tumors. © 2006 Elsevier Inc. All rights reserved. |
| Keywords: | immunohistochemistry; adult; controlled study; human tissue; protein expression; aged; aged, 80 and over; middle aged; human cell; major clinical study; dna-binding proteins; genetic analysis; dna repair; cohort studies; tumor markers, biological; down-regulation; high throughput screening; colorectal tumor; colon cancer; tissue array analysis; tissue microarray; ku antigen; colorectal neoplasms, hereditary nonpolyposis; ku70; antigens, nuclear; ku80; tissue array |
| Journal Title: | Human Pathology |
| Volume: | 37 |
| Issue: | 4 |
| ISSN: | 0046-8177 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2006-04-01 |
| Start Page: | 448 |
| End Page: | 452 |
| Language: | English |
| DOI: | 10.1016/j.humpath.2005.11.016 |
| PUBMED: | 16564919 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 4 June 2012" - "CODEN: HPCQA" - "Source: Scopus" |
