Decreased expression of Ku70/Ku80 proteins in malignant melanomas of the oral cavity Journal Article
| Authors: | Korabiowska, M.; Tscherny, M.; Grohmann, U.; Hönig, J. F.; Bartkowski, S. B.; Cordon-Cardo, C.; Brinck, U. |
| Article Title: | Decreased expression of Ku70/Ku80 proteins in malignant melanomas of the oral cavity |
| Abstract: | Ku70/80 are genes responsible for the repairing of DNA double-strand breaks and they function as a regulatory subunit of the DNA - dependent protein kinase. Their expression has not yet been investigated in malignant melanomas of the oral cavity. These tumours are characterized by very poor prognosis and etiology independent of UV-radiation. We investigated 29 malignant melanomas of the oral cavity for the expression of Ku70/80 proteins. Ku70 expression was preserved in 21 out of 29 tumours and the percentage of Ku70 - positive cells did not exceed 76%. Ku80 was found in 19 out of 29 tumours and the percentage of Ku80-positive cells peaked at 62%. Correlations between Ku70 and Ku80 expression were lost (p>0.05). We conclude that decreased Ku70/80 expression in malignant melanomas of the oral cavity and loss of correlation between these markers may, influence progression of oral melanomas. |
| Keywords: | immunohistochemistry; survival; breast; radiation; dna; microsatellite instability; carcinoma; mutations; colorectal-cancer; kinase; ku70; ku80; catalytic subunit; oral melanomas; double-strand repair |
| Journal Title: | Anticancer Research |
| Volume: | 22 |
| Issue: | 1A |
| ISSN: | 0250-7005 |
| Publisher: | International Institute of Anticancer Research |
| Date Published: | 2002-01-01 |
| Start Page: | 193 |
| End Page: | 196 |
| Language: | English |
| ACCESSION: | WOS:000175351900030 |
| PROVIDER: | wos |
| PUBMED: | 12017286 |
| Notes: | Article -- Source: Wos |
