Immunity to fungi Journal Article
| Authors: | Hohl, T. M.; Rivera, A.; Pamer, E. G. |
| Article Title: | Immunity to fungi |
| Abstract: | Innate and adaptive immune responses target pathogenic fungi and provide defense against fungal infections. Recent studies demonstrate that specific host receptors recognize ligands that are unique to fungi and activate signaling cascades that lead to phagocytosis of fungi, generation of pro-inflammatory mediators, formation of reactive oxygen species, trafficking of inflammatory cells to sites of infection, and initiation of adaptive immune responses. Greater understanding of the molecular mechanisms that underlie antifungal defense has provided a framework for the investigation of protective vaccines and strategies for therapeutic adoptive cell transfer. © 2006 Elsevier Ltd. All rights reserved. |
| Keywords: | signal transduction; protein expression; unclassified drug; review; drug potentiation; nonhuman; cd8+ t lymphocyte; animals; dendritic cell; inflammation; protein binding; antifungal agent; inflammatory cell; molecular mechanics; cd4+ cd25+ t lymphocyte; immune response; recombinant antibody; gamma interferon; saccharomyces cerevisiae; cd4+ t lymphocyte; reactive oxygen metabolite; adoptive transfer; cytokine production; immunity; macrophage; phagocytosis; cytokine release; candidiasis; mycosis; dectin 1; myeloid differentiation factor 88; toll like receptor; aspergillus fumigatus; fungi; aspergillosis; interleukin 12; immunocompetent cell; fungus growth; internalization; helper cell; tetanus toxoid; tumor necrosis factor; antifungal activity; autologous bone marrow transplantation; histoplasmosis; mycoses; immunity, natural; mannose receptor; lectin receptor; cd209 antigen; laminaran; pentraxin; pentraxin 3; paracoccidioides brasiliensis |
| Journal Title: | Current Opinion in Immunology |
| Volume: | 18 |
| Issue: | 4 |
| ISSN: | 0952-7915 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2006-08-01 |
| Start Page: | 465 |
| End Page: | 472 |
| Language: | English |
| DOI: | 10.1016/j.coi.2006.05.003 |
| PUBMED: | 16765580 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 42" - "Export Date: 4 June 2012" - "CODEN: COPIE" - "Source: Scopus" |
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