Ly6G(+) neutrophils are dispensable for defense against systemic Listeria monocytogenes infection Journal Article
| Authors: | Shi, C.; Hohl, T. M.; Leiner, I.; Equinda, M. J.; Fan, X.; Pamer, E. G. |
| Article Title: | Ly6G(+) neutrophils are dispensable for defense against systemic Listeria monocytogenes infection |
| Abstract: | Listeria monocytogenes is a facultative intracellular bacterium that causes systemic infections in immunocompromised hosts. Early recruitment of myeloid cells, including inflammatory monocytes and neutrophils, to sites of L. monocytogenes infection is essential for the control of infection and host survival. Because previous experimental studies used depleting or blocking Abs that affected both inflammatory monocytes and neutrophils, the relative contributions of these cell populations to defense against L. monocytogenes infection remain incompletely defined. In this article, we used highly selective depletion strategies to either deplete inflammatory monocytes or neutrophils from L. monocytogenes-infected mice and demonstrate that neutrophils are dispensable for early and late control of infection. In contrast, inflammatory monocytes are essential for bacterial clearance during the innate and adaptive phases of the immune response to L. monocytogenes infection. Copyright © 2011 by The American Association of Immunologists, Inc. |
| Keywords: | controlled study; unclassified drug; nonhuman; animal cell; mouse; animal tissue; animal experiment; neutrophil; innate immunity; monocyte; adaptive immunity; infection control; listeriosis; listeria monocytogenes; cell surface protein; ly6g protein; bacterial clearance; monocyte depletion; neutrophil depletion; procedures concerning cells |
| Journal Title: | Journal of Immunology |
| Volume: | 187 |
| Issue: | 10 |
| ISSN: | 0022-1767 |
| Publisher: | The American Association of Immunologists, Inc |
| Date Published: | 2011-11-15 |
| Start Page: | 5293 |
| End Page: | 5298 |
| Language: | English |
| DOI: | 10.4049/jimmunol.1101721 |
| PROVIDER: | scopus |
| PMCID: | PMC3208088 |
| PUBMED: | 21976773 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 9 December 2011" - "CODEN: JOIMA" - "Source: Scopus" |
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