Selective expansion of the monocytic lineage directed by bacterial infection Journal Article
| Authors: | Serbina, N. V.; Hohl, T. M.; Cherny, M.; Pamer, E. G. |
| Article Title: | Selective expansion of the monocytic lineage directed by bacterial infection |
| Abstract: | CCR2-mediated recruitment of Ly6C<sup>high</sup> monocytes is essential for defense against a range of microbial pathogens. Although our understanding of monocyte trafficking to inflammatory sites is increasing, how innate immune inflammation influences monocyte development and maturation during microbial infection remains undefined. Herein, we demonstrate that infection with the intracellular bacterial pathogen Listeria monocytogenes specifically and selectively promotes monopoiesis. Systemic infection with virulent L. monocytogenes induces marked proliferation of bone marrow monocyte precursors and results in depletion of myeloid progenitors. Proliferation of monocyte precursors correlates with the intensity of systemic infection and is unaffected by the density of monocytes in the bone marrow. Although MyD88/Trif-mediated signaling is not required for early emigration of the mature monocyte population from the bone marrow, replenishment of monocyte populations depends on MyD88/Trif. Our studies demonstrate that TLR-mediated signals play an essential role in the maintenance of monocyte homeostasis during systemic bacterial infection. Copyright © 2009 by The American Association of Immunologists, Inc. |
| Keywords: | controlled study; nonhuman; cell proliferation; animal cell; mouse; animal; cytology; metabolism; mouse mutant; animals; mice; mice, knockout; bone marrow cells; bone marrow; animal experiment; animal model; cell population; bacterial virulence; physiology; cell lineage; stem cell; t lymphocyte receptor; immunology; cell density; bone marrow cell; monocyte; monocytes; homeostasis; bacterial infection; bacterial infections; myeloid progenitor cell; cell expansion; myeloid differentiation factor 88; toll like receptor; listeriosis; listeria monocytogenes; neutrophil chemotaxis; chemotaxis, leukocyte; listeria infections; toll like receptor adaptor molecule 1; ticam1 protein, human; vesicular transport adaptor protein; intracellular signaling; leukocyte migration; monocyte macrophage precursor cell; adaptor proteins, vesicular transport; monocyte-macrophage precursor cells; toll-like receptors |
| Journal Title: | Journal of Immunology |
| Volume: | 183 |
| Issue: | 3 |
| ISSN: | 0022-1767 |
| Publisher: | The American Association of Immunologists, Inc |
| Date Published: | 2009-08-01 |
| Start Page: | 1900 |
| End Page: | 1910 |
| Language: | English |
| DOI: | 10.4049/jimmunol.0900612 |
| PUBMED: | 19596996 |
| PROVIDER: | scopus |
| PMCID: | PMC2753883 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 5" - "Export Date: 30 November 2010" - "CODEN: JOIMA" - "Source: Scopus" |
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