Sequential myD88-independent and -dependent activation of innate immune responses to intracellular bacterial infection Journal Article
| Authors: | Serbina, N. V.; Kuziel, W.; Flavell, R.; Akira, S.; Rollins, B.; Pamer, E. G. |
| Article Title: | Sequential myD88-independent and -dependent activation of innate immune responses to intracellular bacterial infection |
| Abstract: | Microbial infections induce chemokine and cytokine cascades that coordinate innate immune defenses. Infection with the intracellular bacterial pathogen Listeria monocytogenes induces CCR2-dependent monocyte recruitment and activation, an essential response for host survival. Herein we show that invasive L. monocytogenes, but not killed or noninvasive bacteria, induce secretion of MCP-1, the requisite chemokine for monocyte recruitment. Induction of MCP-1, but not TNF or IL-12, following L. monocytogenes infection is MyD88 independent. Consistent with these results, MyD88 deficiency does not impair monocyte recruitment to L. monocytogenes infected spleens, but prevents monocyte activation. Our results indicate that distinct microbial signals activate innate immune responses in an ordered, step-wise fashion, providing a mechanism to specify and modulate antimicrobial effector functions. |
| Keywords: | controlled study; nonhuman; animal cell; mouse; animals; mice; animal tissue; spleen; animal experiment; animal model; dendritic cells; immune response; regulatory mechanism; chemotaxis; protein induction; adaptor proteins, signal transducing; immunomodulation; protein deficiency; monocyte; macrophages; cytokine release; bacterial infection; cell activation; cell invasion; myeloid differentiation factor 88; interleukin 12; monocyte chemotactic protein 1; listeriosis; listeria monocytogenes; chemokine ccl2; listeria infections; antigens, differentiation; tumor necrosis factor; receptors, immunologic; bacterial immunity; experimental infection; antimicrobial activity; microbial activity; immunity, natural; priority journal; article |
| Journal Title: | Immunity |
| Volume: | 19 |
| Issue: | 6 |
| ISSN: | 1074-7613 |
| Publisher: | Cell Press |
| Date Published: | 2003-12-01 |
| Start Page: | 891 |
| End Page: | 901 |
| Language: | English |
| DOI: | 10.1016/s1074-7613(03)00330-3 |
| PUBMED: | 14670305 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 12 September 2014 -- Source: Scopus |
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