TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection Journal Article
| Authors: | Serbina, N. V.; Salazar-Mather, T. P.; Biron, C. A.; Kuziel, W. A.; Pamer, E. G. |
| Article Title: | TNF/iNOS-producing dendritic cells mediate innate immune defense against bacterial infection |
| Abstract: | Dendritic cells (DCs) present microbial antigens to T cells and provide inflammatory signals that modulate T cell differentiation. While the role of DCs in adaptive immunity is well established, their involvement in innate immune defenses is less well defined. We have identified a TNF/iNOS-producing (Tip)-DC subset in spleens of Listeria monocytogenes-infected mice that is absent from CCR2-deficient mice. The absence of Tip-DCs results in profound TNF and iNOS deficiencies and an inability to clear primary bacterial infection. CD8 and CD4 T cell responses to L. monocytogenes antigens are preserved in CCR2-deficient mice, indicating that Tip-DCs are not essential for T cell priming. Tip-DCs, as the predominant source of TNF and iNOS during L. monocytogenes infection, orchestrate and mediate innate immune defense against this intracellular bacterial pathogen. |
| Keywords: | controlled study; nonhuman; cd8 antigen; t lymphocyte; animal cell; mouse; animals; mice; animal tissue; spleen; dendritic cell; animal experiment; animal model; mice, inbred c57bl; dendritic cells; tumor necrosis factor-alpha; protein deficiency; immunity; cd4 antigen; bacterial infection; chemokine receptor ccr2; listeriosis; listeria monocytogenes; listeria infections; receptors, chemokine; nitric oxide synthase; antigens, differentiation; tumor necrosis factor; nitric oxide synthase type ii; antigens, cd11b; antigens, cd11c; immunity, natural; bacterial antigen; priority journal; article |
| Journal Title: | Immunity |
| Volume: | 19 |
| Issue: | 1 |
| ISSN: | 1074-7613 |
| Publisher: | Cell Press |
| Date Published: | 2003-07-01 |
| Start Page: | 59 |
| End Page: | 70 |
| Language: | English |
| DOI: | 10.1016/s1074-7613(03)00171-7 |
| PUBMED: | 12871639 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 12 September 2014 -- Source: Scopus |
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