Immune responses to Aspergillus fumigatus infections Journal Article
| Authors: | Rivera, A.; Hohl, T.; Pamer, E. G. |
| Article Title: | Immune responses to Aspergillus fumigatus infections |
| Abstract: | Aspergillus fumigatus is an important fungal pathogen of the immunocompromised host. Innate inflammatory and adaptive T cell responses contribute to defense against this pathogen. Toll-like receptors are involved in the activation of innate immune defenses against fungal spores and hyphae and contribute to the recruitment of inflammatory cells to sites of infection. T cell responses to A. fumigatus are rapid and robust, and their differentiation is influenced by the metabolic activity of spores. Ongoing investigations of immune responses to A. fumigatus are likely to provide opportunities to enhance defenses against this pathogen in the immunocompromised host. © 2006 American Society for Blood and Marrow Transplantation. |
| Keywords: | protein expression; nonhuman; protein function; lymphocyte proliferation; t lymphocyte; t-lymphocytes; animals; dendritic cell vaccine; interleukin 10; interleukin 13; interleukin 4; myeloperoxidase; inflammation; immunoglobulin enhancer binding protein; cell differentiation; enzyme activity; lymphocyte differentiation; toll like receptor 4; th2 cell; cellular immunity; gamma interferon; cell movement; allogeneic hematopoietic stem cell transplantation; cytokine production; innate immunity; th1 cell; infection prevention; immune deficiency; immunocompromised host; voriconazole; myeloid differentiation factor 88; toll like receptor 2; aspergillus fumigatus; fungus hyphae; aspergillosis; fungus spore; lung aspergillosis; interleukin 12; infection sensitivity; cd14 antigen; tumor necrosis factor; antifungal activity; spores, fungal; toll-like receptors; immunization; interleukin 18; toll like receptor 9; macrophage inflammatory protein 2; infection resistance; infliximab; toll like receptor 1; immunity, natural; macrophage inflammatory protein 1alpha; fungal infections; toll like receptor 10; toll like receptor 6; fungus immunity |
| Journal Title: | Biology of Blood and Marrow Transplantation |
| Volume: | 12 |
| Issue: | 1 Suppl.1 |
| ISSN: | 1083-8791 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2006-01-01 |
| Start Page: | 47 |
| End Page: | 49 |
| Language: | English |
| DOI: | 10.1016/j.bbmt.2005.09.007 |
| PUBMED: | 16399584 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 15" - "Export Date: 4 June 2012" - "CODEN: BBMTF" - "Source: Scopus" |
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