Cancer metastasis: Building a framework Journal Article
| Authors: | Gupta, G. P.; Massague, J. |
| Article Title: | Cancer metastasis: Building a framework |
| Abstract: | Metastasis occurs when genetically unstable cancer cells adapt to a tissue microenvironment that is distant from the primary tumor. This process involves both the selection of traits that are advantageous to cancer cells and the concomitant recruitment of traits in the tumor stroma that accommodate invasion by metastatic cells. Recent conceptual and technological advances promote our understanding of the origins and nature of cancer metastasis. © 2006 Elsevier Inc. All rights reserved. |
| Keywords: | signal transduction; review; cancer growth; nonhuman; bone metastasis; neoplasms; cell proliferation; phenotype; animals; cell survival; metastasis; breast cancer; basement membrane; cell population; cell heterogeneity; evolution, molecular; extracellular matrix; liver metastasis; cancer cell; medical technology; cell membrane; neoplasm metastasis; genetic stability; antibody specificity; microenvironment; cell adhesion; cell invasion; cell motility; genetic selection; dormancy; extravasation; neoplasm circulating cells |
| Journal Title: | Cell |
| Volume: | 127 |
| Issue: | 4 |
| ISSN: | 0092-8674 |
| Publisher: | Cell Press |
| Date Published: | 2006-11-17 |
| Start Page: | 679 |
| End Page: | 695 |
| Language: | English |
| DOI: | 10.1016/j.cell.2006.11.001 |
| PUBMED: | 17110329 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 613" - "Export Date: 4 June 2012" - "CODEN: CELLB" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work