Metastasis Review
| Authors: | Gerstberger, S.; Jiang, Q.; Ganesh, K. |
| Review Title: | Metastasis |
| Abstract: | Most cancer-associated deaths occur due to metastasis, yet our understanding of metastasis as an evolving, heterogeneous, systemic disease and of how to effectively treat it is still emerging. Metastasis requires the acquisition of a succession of traits to disseminate, variably enter and exit dormancy, and colonize distant organs. The success of these events is driven by clonal selection, the potential of metastatic cells to dynamically transition into distinct states, and their ability to co-opt the immune environment. Here, we review the main principles of metastasis and highlight emerging opportunities to develop more effective therapies for metastatic cancer. © 2023 Elsevier Inc. |
| Keywords: | cancer survival; event free survival; gene mutation; somatic mutation; review; cancer growth; nonhuman; pancreas cancer; lymph node metastasis; neoplasm; neoplasms; cell proliferation; cell death; cell cycle; melanoma; metastasis; breast cancer; gene expression; antineoplastic activity; pathology; dna methylation; cancer resistance; stem cell; rna binding protein; tumor suppressor gene; antigen presentation; immune response; neoplastic stem cells; cancer cell; cancer stem cell; neoplasm metastasis; micrometastasis; cell migration; natural killer cell; oxidative stress; cell regeneration; heterozygosity loss; transfer rna; macrophage; immunosurveillance; immunocompetent cell; phylogeny; tumor microenvironment; phosphoglycerate dehydrogenase; immune evasion; triple negative breast cancer; epithelial mesenchymal transition; histone modification; macropinocytosis; immune checkpoint inhibitor; mitochondrial rna; humans; human; pembrolizumab; single cell rna seq; transendothelial and transepithelial migration |
| Journal Title: | Cell |
| Volume: | 186 |
| Issue: | 8 |
| ISSN: | 0092-8674 |
| Publisher: | Cell Press |
| Date Published: | 2023-04-13 |
| Start Page: | 1564 |
| End Page: | 1579 |
| Language: | English |
| DOI: | 10.1016/j.cell.2023.03.003 |
| PUBMED: | 37059065 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 1 May 2023 -- Source: Scopus |
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