Surviving at a distance: Organ-specific metastasis Journal Article
| Authors: | Obenauf, A. C.; Massagué, J. |
| Article Title: | Surviving at a distance: Organ-specific metastasis |
| Abstract: | The clinical manifestation of metastasis in a vital organ is the final stage of cancer progression and the main culprit of cancer-related mortality. Once established, metastasis is devastating, but only a small proportion of the cancer cells that leave a tumor succeed at infiltrating, surviving, and ultimately overtaking a distant organ. The bottlenecks that challenge cancer cells in newly invaded microenvironments are organ-specific and consequently demand distinct mechanisms for metastatic colonization. We review the metastatic traits that allow cancer cells to colonize distinct organ sites. © 2015 Elsevier Ltd. |
| Keywords: | metastasis; metastatic colonization; cancer; organ-specific metastasis |
| Journal Title: | Trends in Cancer |
| Volume: | 1 |
| Issue: | 1 |
| ISSN: | 2405-8025 |
| Publisher: | Cell Press |
| Date Published: | 2015-09-01 |
| Start Page: | 76 |
| End Page: | 91 |
| Language: | English |
| DOI: | 10.1016/j.trecan.2015.07.009 |
| PROVIDER: | scopus |
| PMCID: | PMC4673677 |
| PUBMED: | 26693180 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 3 March 2016 -- Source: Scopus |
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