Antigens of melanocytes and melanoma Journal Article
| Authors: | Lynch, S. A.; Bouchard, B. N.; Vijayasaradhi, S.; Yuasa, H.; Houghton, A. N. |
| Article Title: | Antigens of melanocytes and melanoma |
| Abstract: | Melanoma is a valuable model to study phenotypic traits that are regulated during cell differentiation and malignant transformation. Melanoma cells display extensive phenotypic and antigenic heterogeneity. Studies of this attribute have provided insight into events that take place during normal melanocyte differentiation and give clues to traits that contribute to malignancy. It is possible that the phenotypic and genotypic heterogeneity present among melanoma cells within a single lesion includes a subset of cells with traits that favor tumor progression and metastasis. This review discusses the identification and characterization of antigens expressed by melanoma cells and their potential contribution to melanocyte differentiation and malignant transformation. © 1991 Kluwer Academic Publishers. |
| Keywords: | human cell; review; antigen expression; melanoma; melanocyte; melanocytes; cell differentiation; tumor antigen; cell transformation, neoplastic; antigen; antigens, neoplasm; cell transformation; melanoma cell; melanoma antigen; antigens, differentiation; differentiation; transformation; human; priority journal |
| Journal Title: | Cancer and Metastasis Reviews |
| Volume: | 10 |
| Issue: | 2 |
| ISSN: | 0167-7659 |
| Publisher: | Springer |
| Date Published: | 1991-06-01 |
| Start Page: | 141 |
| End Page: | 150 |
| Language: | English |
| DOI: | 10.1007/bf00049411 |
| PUBMED: | 1873854 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 27 September 2019 -- Source: Scopus |
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