Origins of Metastatic Traits Journal Article
| Authors: | Vanharanta, S.; Massague, J. |
| Article Title: | Origins of Metastatic Traits |
| Abstract: | How cancer cells acquire the competence to colonize distant organs remains a central question in cancer biology. Tumors can release large numbers of cancer cells into the circulation, but only a small proportion of these cells survive on infiltrating distant organs and even fewer form clinically meaningful metastases. During the past decade, many predictive gene signatures and specific mediators of metastasis have been identified, yet how cancer cells acquire these traits has remained obscure. Recent experimental work and high-resolution sequencing of human tissues have started to reveal the molecular and tumor evolutionary principles that underlie the emergence of metastatic traits. © 2013 Elsevier Inc. |
| Journal Title: | Cancer Cell |
| Volume: | 24 |
| Issue: | 4 |
| ISSN: | 1535-6108 |
| Publisher: | Cell Press |
| Date Published: | 2013-10-14 |
| Start Page: | 410 |
| End Page: | 421 |
| Language: | English |
| DOI: | 10.1016/j.ccr.2013.09.007 |
| PROVIDER: | scopus |
| PUBMED: | 24135279 |
| PMCID: | PMC3998120 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 1 November 2013" - "CODEN: CCAEC" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
-
10Vanharanta -
388Massague
Related MSK Work