Regulatory T cells in the context: Deciphering the dynamic interplay with the tissue environment Review

  


Authors: Huang, X.; Rudensky, A. Y.
Review Title: Regulatory T cells in the context: Deciphering the dynamic interplay with the tissue environment
Abstract: The delicate balance between protective immunity against pathogens and the prevention of autoimmunity requires finely tuned generation and function of regulatory CD4+ T (Treg) cells. Here, we review recent progress in the understanding of a complex set of cues, which converge on Treg cells in lymphoid and nonlymphoid organs and in tumors and how these cues modulate Treg functions. We highlight the versatility of Treg cells underlying their ability to dynamically adapt to local microenvironments and perform a wide range of functions that extend beyond the archetypal role of Treg cells in moderating adverse effects of immune response-associated inflammation and in suppressing autoimmunity. © 2024 Elsevier Ltd
Keywords: review; nonhuman; inflammation; regulatory t lymphocyte; immune response; autoimmunity; microenvironment; cd4 antigen; therapy; pharmacology
Journal Title: Current Opinion in Immunology
Volume: 89
ISSN: 0952-7915
Publisher: Elsevier Inc.  
Date Published: 2024-08-01
Start Page: 102453
Language: English
DOI: 10.1016/j.coi.2024.102453
PROVIDER: scopus
PUBMED: 39173413
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85201394185&doi=10.1016%2fj.coi.2024.102453&partnerID=40&md5=b42f9ccc8de58ce04dfac01de7aa9bd2
Notes: The MSK Cancer Center Support Grant (P30 CA008748) is acknowledge in the PDF -- Corresponding authors are MSK authors: Xiao Huang and Alexander Y Rudensky -- Source: Scopus
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MSK Authors
  1. Alexander Rudensky
    156 Rudensky
  2. Xiao Huang
    2 Huang
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