CD4(+) regulatory T cells control T(H)17 responses in a stat3-dependent manner Journal Article
| Authors: | Chaudhry, A.; Rudra, D.; Treuting, P.; Samstein, R. M.; Liang, Y.; Kas, A.; Rudensky, A. Y. |
| Article Title: | CD4(+) regulatory T cells control T(H)17 responses in a stat3-dependent manner |
| Abstract: | Distinct classes of protective immunity are guided by activation of STAT transcription factor family members in response to environmental cues. CD4 (+) regulatory T cells (T(regs)) suppress excessive immune responses, and their deficiency results in a lethal, multi-organ autoimmune syndrome characterized by T helper 1 (T(H)1) and T helper 2 (T (H)2) CD4(+) T cell-dominated lesions. Here we show that pathogenic T(H)17 responses in mice are also restrained by T (regs). This suppression was lost upon T(reg)-specific ablation of Stat3, a transcription factor critical for T(H)17 differentiation, and resulted in the development of a fatal intestinal inflammation. These findings suggest that T(regs) adapt to their environment by engaging distinct effector response-specific suppression modalities upon activation of STAT proteins that direct the corresponding class of the immune response. |
| Keywords: | controlled study; protein phosphorylation; hepatitis; nonhuman; lymph nodes; transcription factor foxp3; lymphocyte proliferation; forkhead transcription factors; mouse; animals; mice; animal tissue; mus; stat3 protein; anemia; spleen; protein protein interaction; animal experiment; protein; weight reduction; phosphorylation; mice, inbred c57bl; cell lineage; lymphocyte differentiation; regulatory t lymphocyte; lymphocyte activation; cytokines; cellular immunity; t-lymphocytes, regulatory; splenomegaly; cd4+ t lymphocyte; enteritis; stat3 transcription factor; rodent; interleukin 17; environmental cue; immunity; pathogenicity; colon disease; lipidosis; rectum prolapse; th17 cell; inflammatory bowel diseases; interferon-gamma; interleukin-17; intestine, large; receptors, ccr6; t-lymphocyte subsets; t-lymphocytes, helper-inducer |
| Journal Title: | Science |
| Volume: | 326 |
| Issue: | 5955 |
| ISSN: | 0036-8075 |
| Publisher: | American Association for the Advancement of Science |
| Date Published: | 2009-11-13 |
| Start Page: | 986 |
| End Page: | 991 |
| Language: | English |
| DOI: | 10.1126/science.1172702 |
| PUBMED: | 19797626 |
| PROVIDER: | scopus |
| PMCID: | PMC4408196 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 45" - "Export Date: 30 November 2010" - "CODEN: SCIEA" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work