An essential role for the IL-2 receptor in T-reg cell function Journal Article
| Authors: | Chinen, T.; Kannan, A. K.; Levine, A. G.; Fan, X. Y.; Klein, U.; Zheng, Y.; Gasteiger, G.; Feng, Y. Q.; Fontenot, J. D.; Rudensky, A. Y. |
| Article Title: | An essential role for the IL-2 receptor in T-reg cell function |
| Abstract: | Regulatory T cells (T-reg cells), which have abundant expression of the interleukin 2 receptor (IL-2R), are reliant on IL-2 produced by activated T cells. This feature indicates a key role for a simple network based on the consumption of IL-2 by T-reg cells in their suppressor function. However, congenital deficiency in IL-2R results in reduced expression of the T-reg cell lineage-specification factor Foxp3, which has confounded experimental efforts to understand the role of IL-2R expression and signaling in the suppressor function of T-reg cells. Using genetic gain-and loss-of-function approaches, we found that capture of IL-2 was dispensable for the control of CD4(+) T cells but was important for limiting the activation of CD8(+) T cells, and that IL-2R-dependent activation of the transcription factor STAT5 had an essential role in the suppressor function of T-reg cells separable from signaling via the T cell antigen receptor. |
| Keywords: | transcription factor foxp3; gene; in-vivo; interleukin-2; expression; induction; cutting edge; lineage; stat5; suppressor function |
| Journal Title: | Nature Immunology |
| Volume: | 17 |
| Issue: | 11 |
| ISSN: | 1529-2908 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2016-11-01 |
| Start Page: | 1322 |
| End Page: | 1333 |
| Language: | English |
| ACCESSION: | WOS:000386193200012 |
| DOI: | 10.1038/ni.3540 |
| PROVIDER: | wos |
| PMCID: | PMC5071159 |
| PUBMED: | 27595233 |
| Notes: | Article -- Source: Wos |
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