Continuous requirement for the TCR in regulatory T cell function Journal Article


Authors: Levine, A. G.; Arvey, A.; Jin, W.; Rudensky, A. Y.
Article Title: Continuous requirement for the TCR in regulatory T cell function
Abstract: Foxp3+ regulatory T cells (Treg cells) maintain immunological tolerance, and their deficiency results in fatal multiorgan autoimmunity. Although heightened signaling via the T cell antigen receptor (TCR) is critical for the differentiation of Treg cells, the role of TCR signaling in Treg cell function remains largely unknown. Here we demonstrated that inducible ablation of the TCR resulted in Treg cell dysfunction that could not be attributed to impaired expression of the transcription factor Foxp3, decreased expression of Treg cell signature genes or altered ability to sense and consume interleukin 2 (IL-2). Instead, TCR signaling was required for maintaining the expression of a limited subset of genes comprising 25% of the activated Treg cell transcriptional signature. Our results reveal a critical role for the TCR in the suppressor capacity of Treg cells.
Keywords: signal transduction; protein expression; transcription factor foxp3; interleukin 2; cell differentiation; in vitro study; t lymphocyte receptor; immunological tolerance; regulatory t lymphocyte; homeostasis; t lymphocyte activation; interferon regulatory factor 4; article
Journal Title: Nature Immunology
Volume: 15
Issue: 11
ISSN: 1529-2908
Publisher: Nature Publishing Group  
Date Published: 2014-11-01
Start Page: 1070
End Page: 1078
Language: English
DOI: 10.1038/ni.3004
PROVIDER: scopus
PMCID: PMC4205268
PUBMED: 25263123
DOI/URL:
Notes: Export Date: 1 December 2014 -- Source: Scopus
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  1. Alexander Rudensky
    156 Rudensky
  2. Wei Jin
    2 Jin
  3. Aaron J. Arvey
    20 Arvey
  4. Andrew Gould Levine
    8 Levine