Transcriptional control of regulatory T-cell differentiation Conference Paper
| Authors: | Van Der Veeken, J.; Arvey, A.; Rudensky, A. |
| Title: | Transcriptional control of regulatory T-cell differentiation |
| Conference Title: | 78th Cold Spring Harbor Symposium on Quantitative Biology |
| Abstract: | Regulatory T (Treg) cells are essential for maintaining peripheral tolerance and for limiting excessive inflammatory responses under various conditions. The lineage-specific transcription factor Foxp3 has a critical role in Treg-cell biology. Foxp3 forms large protein complexes and cooperates with environmentally induced transcription factors to shape the Treg-cell transcriptional program. Here, we discuss mechanisms of gene regulation that underlie Treg-cell differentiation and function with an emphasis on studies from our laboratory. © 2013 Cold Spring Harbor Laboratory Press. |
| Keywords: | protein expression; promoter region; nonhuman; transcription factor foxp3; apoptosis; cell maturation; protein stability; lymphocyte differentiation; immunological tolerance; regulatory t lymphocyte; epigenetics; cd4+ t lymphocyte; protein induction; gene control; major histocompatibility complex; lymphocyte function; stable expression; human; priority journal; article |
| Journal Title | Cold Spring Harbor Symposia on Quantitative Biology |
| Volume: | 78 |
| Issue: | 1 |
| Conference Dates: | 2013 May 29-Jun 3 |
| Conference Location: | Cold Spring Harbor, NY |
| ISBN: | 0091-7451 |
| Publisher: | Cold Spring Harbor Laboratory Press |
| Date Published: | 2013-01-01 |
| Start Page: | 215 |
| End Page: | 222 |
| Language: | English |
| DOI: | 10.1101/sqb.2013.78.020289 |
| PROVIDER: | scopus |
| PUBMED: | 24733379 |
| DOI/URL: | |
| Notes: | Export Date: 2 September 2014 -- CODEN: CSHSA -- Source: Scopus |
