Molecular orchestration of differentiation and function of regulatory T cells Journal Article
| Authors: | Lu, L. F. ; Rudensky, A. |
| Article Title: | Molecular orchestration of differentiation and function of regulatory T cells |
| Abstract: | During the last decade, a unique mechanism of negative regulation of immune responses and inflammation by a dedicated population of so-called regulatory T cells (Treg) has become a focus of intensive investigation. Through the discovery of transcription factor Foxp3 as a central molecular determinant of differentiation and function of Treg cells, the complex biology of these cells, including maintenance of immunological tolerance to "self" and regulation of immune responses to pathogens, commensals, and tumors, has become amenable to mechanistic studies. In this review, we discuss the molecular aspects of Treg cell lineage commitment, maintenance, and function. © 2009 by Cold Spring Harbor Laboratory Press. |
| Keywords: | signal transduction; protein expression; review; nonhuman; protein function; transcription factor foxp3; forkhead transcription factors; animal; cytology; animals; cell function; microrna; protein protein interaction; cell differentiation; immunoregulation; gene expression regulation; cd4+ cd25+ t lymphocyte; immunological tolerance; regulatory t lymphocyte; immunology; immune tolerance; t-lymphocytes, regulatory; cd4+ t lymphocyte; cd4-positive t-lymphocytes; micrornas; cytotoxic t lymphocyte antigen 4; glucocorticoid induced tumor necrosis factor receptor; forkhead transcription factor; differentiation; t lymphocytes; tolerance; transcriptional regulation; interferon regulatory factor 4; interleukin 2 receptor alpha; neuropilin 1; cell secretion; interleukin-2 receptor alpha subunit |
| Journal Title: | Genes and Development |
| Volume: | 23 |
| Issue: | 11 |
| ISSN: | 0890-9369 |
| Publisher: | Cold Spring Harbor Laboratory Press |
| Date Published: | 2009-06-01 |
| Start Page: | 1270 |
| End Page: | 1282 |
| Language: | English |
| DOI: | 10.1101/gad.1791009 |
| PUBMED: | 19487568 |
| PROVIDER: | scopus |
| PMCID: | PMC2763538 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 13" - "Export Date: 30 November 2010" - "CODEN: GEDEE" - "Source: Scopus" |
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