Control of Regulatory T Cell Lineage Commitment and Maintenance Journal Article
| Authors: | Josefowicz, S. Z.; Rudensky, A. |
| Article Title: | Control of Regulatory T Cell Lineage Commitment and Maintenance |
| Abstract: | Foxp3-expressing regulatory T (Treg) cells suppress pathology mediated by immune responses against self and foreign antigens and commensal microorganisms. Sustained expression of the transcription factor Foxp3, a key distinguishing feature of Treg cells, is required for their differentiation and suppressor function. In addition, Foxp3 expression prevents deviation of Treg cells into effector T cell lineages and confers dependence of Treg cell survival and expansion on growth factors, foremost interleukin-2, provided by activated effector T cells. In this review we discuss Treg cell differentiation and maintenance with a particular emphasis on molecular regulation of Foxp3 expression, arguably a key to mechanistic understanding of biology of regulatory T cells. © 2009 Elsevier Inc. All rights reserved. |
| Keywords: | signal transduction; protein expression; review; nonhuman; transcription factor foxp3; forkhead transcription factors; animals; cell survival; interleukin 2; protein kinases; cell differentiation; cell lineage; immunoregulation; gene expression regulation; lymphocyte differentiation; t lymphocyte receptor; regulatory t lymphocyte; cytokines; transcription regulation; receptors, antigen, t-cell; t-lymphocytes, regulatory; thymus gland; cytokine production; t-lymphocyte subsets; thymocyte |
| Journal Title: | Immunity |
| Volume: | 30 |
| Issue: | 5 |
| ISSN: | 1074-7613 |
| Publisher: | Cell Press |
| Date Published: | 2009-05-22 |
| Start Page: | 616 |
| End Page: | 625 |
| Language: | English |
| DOI: | 10.1016/j.immuni.2009.04.009 |
| PUBMED: | 19464984 |
| PROVIDER: | scopus |
| PMCID: | PMC4410181 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 72" - "Export Date: 30 November 2010" - "CODEN: IUNIE" - "Source: Scopus" |
