Principles of regulatory T cell function Review

  


Authors: Dikiy, S.; Rudensky, A. Y.
Review Title: Principles of regulatory T cell function
Abstract: Regulatory T (Treg) cells represent a distinct lineage of cells of the adaptive immune system indispensable for forestalling fatal autoimmune and inflammatory pathologies. The role of Treg cells as principal guardians of the immune system can be attributed to their ability to restrain all currently recognized major types of inflammatory responses through modulating the activity of a wide range of cells of the innate and adaptive immune system. This broad purview over immunity and inflammation is afforded by the multiple modes of action Treg cells exert upon their diverse molecular and cellular targets. Beyond the suppression of autoimmunity for which they were originally recognized, Treg cells have been implicated in tissue maintenance, repair, and regeneration under physiologic and pathologic conditions. Herein, we discuss the current and emerging understanding of Treg cell effector mechanisms in the context of the basic properties of Treg cells that endow them with such functional versatility. © 2023 Elsevier Inc.
Keywords: human cell; review; cell function; immune system; inflammation; immunoregulation; regeneration; regulatory t lymphocyte; t-lymphocytes, regulatory; autoimmunity; immunosuppressive treatment; homeostasis; regulatory t cells; immune suppression; immune regulation; humans; human
Journal Title: Immunity
Volume: 56
Issue: 2
ISSN: 1074-7613
Publisher: Cell Press  
Date Published: 2023-02-14
Start Page: 240
End Page: 255
Language: English
DOI: 10.1016/j.immuni.2023.01.004
PUBMED: 36792571
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85147793762&doi=10.1016%2fj.immuni.2023.01.004&partnerID=40&md5=bc08b077982f357a5fcab39204d5a030
Notes: The MSK Cancer Center Support Grant (P30 CA008748) is acknowledged in PubMed and PDF -- Corresponding author is MSK authors: Stanislav Dikiy, Alexander Y. Rudensky -- Source: Scopus
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MSK Authors
  1. Alexander Rudensky
    156 Rudensky
  2. Stanislav Dikiy
    12 Dikiy
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