Control of inflammation by integration of environmental cues by regulatory T cells Journal Article

   

Authors:	Chaudhry, A.; Rudensky, A. Y.
Article Title:	Control of inflammation by integration of environmental cues by regulatory T cells
Abstract:	Tregs have been implicated in control of homeostasis in the immune system and beyond. These cells restrain inflammatory responses to self antigens, commensal microorganisms, allergens, and pathogens and adapt their homeostatic and functional capabilities to a particular environment. In this review, we discuss a general model of integration of environmental cues by Tregs in which specialized Treg homeostatic, migratory, and suppression programs are established in dynamically changing inflammatory environments by maintaining an optimal threshold of activation of transcription factors involved in regulation of the corresponding type of effector immune responses.
Journal Title:	Journal of Clinical Investigation
Volume:	123
Issue:	3
ISSN:	0021-9738
Publisher:	American Society for Clinical Investigation
Date Published:	2013-03-01
Start Page:	939
End Page:	944
Language:	English
DOI:	10.1172/jci57175
PROVIDER:	scopus
PMCID:	PMC3582113
PUBMED:	23454755
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-84874608992&partnerID=40&md5=096a34a42cfca7afa5cb89b3b9349eb9
Notes:	--- - "Export Date: 1 April 2013" - "CODEN: JCINA" - "Source: Scopus"

https://synapse.mskcc.org/synapse/works/has_related_data_chk/38822