Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation Journal Article


Authors: Chaudhry, A.; Samstein, R.; Treuting, P.; Liang, Y.; Pils, M.; Heinrich, J. M.; Jack, R.; Wunderlich, F. T.; Brüning, J.; Muller, W.; Rudensky, A.
Article Title: Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation
Abstract: Effector CD4+ T cell subsets, whose differentiation is facilitated by distinct cytokine cues, amplify the corresponding type of inflammatory response. Regulatory T (Treg) cells integrate environmental cues to suppress particular types of inflammation. In this regard, STAT3, a transcription factor essential for T helper 17 (Th17) cell differentiation, is necessary for Treg cell-mediated control of Th17 cell responses. Here, we showed that anti-inflammatory interleukin-10 (IL-10), and not proinflammatory IL-6 and IL-23 cytokine signaling, endowed Treg cells with the ability to suppress pathogenic Th17 cell responses. Ablation of the IL-10 receptor in Treg cells resulted in selective dysregulation of Th17 cell responses and colitis similar to that observed in mice harboring STAT3-deficient Treg cells. Thus, Treg cells limit Th17 cell inflammation by serving as principal amplifiers of negative regulatory circuits operating in immune effector cells. © 2011 Elsevier Inc.
Keywords: signal transduction; controlled study; nonhuman; animal cell; mouse; animal tissue; stat3 protein; interleukin 10; animal experiment; animal model; regulatory t lymphocyte; immune response; colitis; effector cell; antiinflammatory activity; th17 cell; interleukin receptor
Journal Title: Immunity
Volume: 34
Issue: 4
ISSN: 1074-7613
Publisher: Cell Press  
Date Published: 2011-04-22
Start Page: 566
End Page: 578
Language: English
DOI: 10.1016/j.immuni.2011.03.018
PROVIDER: scopus
PMCID: PMC3088485
PUBMED: 21511185
DOI/URL:
Notes: --- - "Cited By (since 1996): 1" - "Export Date: 23 June 2011" - "CODEN: IUNIE" - "Source: Scopus"
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  1. Alexander Rudensky
    156 Rudensky
  2. Yuqiong Liang
    2 Liang