Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation Journal Article

   

Authors:	Chaudhry, A.; Samstein, R.; Treuting, P.; Liang, Y.; Pils, M.; Heinrich, J. M.; Jack, R.; Wunderlich, F. T.; Brüning, J.; Muller, W.; Rudensky, A.
Article Title:	Interleukin-10 signaling in regulatory T cells is required for suppression of Th17 cell-mediated inflammation
Abstract:	Effector CD4+ T cell subsets, whose differentiation is facilitated by distinct cytokine cues, amplify the corresponding type of inflammatory response. Regulatory T (Treg) cells integrate environmental cues to suppress particular types of inflammation. In this regard, STAT3, a transcription factor essential for T helper 17 (Th17) cell differentiation, is necessary for Treg cell-mediated control of Th17 cell responses. Here, we showed that anti-inflammatory interleukin-10 (IL-10), and not proinflammatory IL-6 and IL-23 cytokine signaling, endowed Treg cells with the ability to suppress pathogenic Th17 cell responses. Ablation of the IL-10 receptor in Treg cells resulted in selective dysregulation of Th17 cell responses and colitis similar to that observed in mice harboring STAT3-deficient Treg cells. Thus, Treg cells limit Th17 cell inflammation by serving as principal amplifiers of negative regulatory circuits operating in immune effector cells. © 2011 Elsevier Inc.
Keywords:	signal transduction; controlled study; nonhuman; animal cell; mouse; animal tissue; stat3 protein; interleukin 10; animal experiment; animal model; regulatory t lymphocyte; immune response; colitis; effector cell; antiinflammatory activity; th17 cell; interleukin receptor
Journal Title:	Immunity
Volume:	34
Issue:	4
ISSN:	1074-7613
Publisher:	Cell Press
Date Published:	2011-04-22
Start Page:	566
End Page:	578
Language:	English
DOI:	10.1016/j.immuni.2011.03.018
PROVIDER:	scopus
PMCID:	PMC3088485
PUBMED:	21511185
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-79954608612&partnerID=40&md5=9a8890a5248cfb1066c6f70074c4d1e1
Notes:	--- - "Cited By (since 1996): 1" - "Export Date: 23 June 2011" - "CODEN: IUNIE" - "Source: Scopus"

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