A distinct function of regulatory T cells in tissue protection Journal Article

Authors: Arpaia, N.; Green, J. A.; Moltedo, B.; Arvey, A.; Hemmers, S.; Yuan, S.; Treuting, P. M.; Rudensky, A. Y.
Article Title: A distinct function of regulatory T cells in tissue protection
Abstract: Summary Regulatory T (Treg) cells suppress immune responses to a broad range of non-microbial and microbial antigens and indirectly limit immune inflammation-inflicted tissue damage by employing multiple mechanisms of suppression. Here, we demonstrate that selective Treg cell deficiency in amphiregulin leads to severe acute lung damage and decreased blood oxygen concentration during influenza virus infection without any measureable alterations in Treg cell suppressor function, antiviral immune responses, or viral load. This tissue repair modality is mobilized in Treg cells in response to inflammatory mediator IL-18 or alarmin IL-33, but not by TCR signaling that is required for suppressor function. These results suggest that, during infectious lung injury, Treg cells have a major direct and non-redundant role in tissue repair and maintenance - distinct from their role in suppression of immune responses and inflammation - and that these two essential Treg cell functions are invoked by separable cues. © 2015 Elsevier Inc.
Keywords: controlled study; protein expression; nonhuman; animal cell; mouse; animal tissue; cell function; animal experiment; animal model; regulatory t lymphocyte; immune response; cytokine production; virus load; influenza; tissue repair; suppressor cell; amphiregulin; influenza virus; orthomyxoviridae; interleukin 18; lung injury; lymphocyte subpopulation; interleukin 33; priority journal; article
Journal Title: Cell
Volume: 162
Issue: 5
ISSN: 0092-8674
Publisher: Cell Press  
Date Published: 2015-08-27
Start Page: 1078
End Page: 1089
Language: English
DOI: 10.1016/j.cell.2015.08.021
PROVIDER: scopus
PUBMED: 26317471
PMCID: PMC4603556
Notes: Export Date: 2 October 2015 -- Source: Scopus
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MSK Authors
  1. Saskia Hemmers
    12 Hemmers
  2. Aaron J. Arvey
    20 Arvey
  3. Nicholas Arpaia
    8 Arpaia
  4. Jesse Allan Green
    3 Green
  5. Shaopeng   Yuan
    1 Yuan