Biology and genetics of extranodal mature T-cell and NK-cell lymphomas and lymphoproliferative disorders Review
| Authors: | Lewis, N. E.; Zhou, T.; Dogan, A. |
| Review Title: | Biology and genetics of extranodal mature T-cell and NK-cell lymphomas and lymphoproliferative disorders |
| Abstract: | The extranodal mature T-cell and NK-cell lymphomas and lymphoproliferative disorders represent a unique group of rare neoplasms with both overlapping and distinct clinicopathological, biological, and genomic features. Their predilection for specific sites, such as the gastrointestinal tract, aerodigestive tract, liver, spleen, and skin/soft tissues, underlies their classification. Recent genomic advances have furthered our understanding of the biology and pathogenesis of these diseases, which is critical for accurate diagnosis, prognostic assessment, and therapeutic decision-making. Here we review clinical, pathological, genomic, and biological features of the following extranodal mature T-cell and NK-cell lymphomas and lymphoproliferative disorders: primary intestinal T-cell and NK-cell neoplasms, hepatosplenic T-cell lymphoma, extranodal NK/T-cell lymphoma, nasal type, and subcutaneous panniculitis-like T-cell lymphoma. © 2023 Ferrata Storti Foundation. All rights reserved. |
| Keywords: | signal transduction; gene mutation; genetics; review; flow cytometry; cd3 antigen; t lymphocyte; t-lymphocytes; biology; cytotoxicity; pathology; dna methylation; carcinogenesis; regulatory t lymphocyte; fluorescence in situ hybridization; epigenetics; heterozygosity; natural killer cell; killer cells, natural; immunophenotyping; lymphoproliferative disease; cd4 antigen; cd5 antigen; interleukin 15; chromosome 8q; nk t cell lymphoma; lymphoproliferative disorders; hepatosplenic t cell lymphoma; cd56 antigen; enteropathy associated t cell lymphoma; humans; human; subcutaneous t cell lymphoma; extranodal natural killer/t-cell lymphoma; lymphoma, extranodal nk-t-cell; extranodal nasal nk/t cell lymphoma; immunoproliferative disease; indolent clonal t cell lymphoproliferative disorder; intestinal t cell lymphoma; monomorphic epitheliotropic intestinal t cell lymphoma; refractory celiac disease |
| Journal Title: | Haematologica |
| Volume: | 108 |
| Issue: | 12 |
| ISSN: | 0390-6078 |
| Publisher: | Ferrata Storti Foundation |
| Date Published: | 2023-12-01 |
| Start Page: | 3261 |
| End Page: | 3277 |
| Language: | English |
| DOI: | 10.3324/haematol.2023.282718 |
| PUBMED: | 38037802 |
| PROVIDER: | scopus |
| PMCID: | PMC10690927 |
| DOI/URL: | |
| Notes: | Review -- Source: Scopus |
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