Transdifferentiation, phenotypic infidelity, progression, and transformation in T/NK-cell neoplasms: Report from the 2021 SH/EAHP workshop Review
| Authors: | Amador, C.; Cook, J. R.; Czader, M.; Duffield, A.; Goodlad, J.; Nejati, R.; Ott, G.; Xiao, W.; Dave, S.; Wasik, M. A.; Dogan, A. |
| Review Title: | Transdifferentiation, phenotypic infidelity, progression, and transformation in T/NK-cell neoplasms: Report from the 2021 SH/EAHP workshop |
| Abstract: | Objectives: Sessions 8 and 9 of the 2021 Society for Hematopathology and the European Association for Haematopathology Workshop aimed to collect examples of transdifferentiation, lineage infidelity, progression, and transformation in precursor and mature T/natural killer (NK)–cell neoplasms. Methods: Twenty-eight cases were submitted and analyzed, with whole-exome sequencing and genome-wide RNA expression analysis performed in a subset of the cases. Results: In session 8, 7 T-lymphoblastic lymphoma/leukemia cases were received that showed transdifferentiation to clonally related mature myeloid hematopoietic neoplasms, including 6 histiocytic/dendritic cell lineage neoplasms and a mast cell sarcoma. Session 9 included 21 mature T-cell neoplasms that were grouped into 3 themes. The first one addressed phenotypic infidelity in mature T-cell lymphomas (TCLs) and included 8 TCLs expressing aberrant antigens, mimicking classic Hodgkin and non-Hodgkin B-cell lymphomas. The second theme addressed disease progression in TCL and included 5 cutaneous T-cell lymphoproliferative disorders and 2 T-cell large granular lymphocyte proliferations with subsequent progression to systemic TCL. The third theme included 6 patients with TCL with T-follicular helper phenotype, mainly angioimmunoblastic T-cell lymphoma, with concurrent/subsequent clonal hematopoiesis or myeloid neoplasms and/ or subsequent/concomitant diffuse large B-cell lymphoma. Conclusions: This cohort of cases allowed us to illustrate, discuss, and review current concepts of transdifferentiation, aberrant antigen expression, and progression in various T/ NK-cell neoplasms. © the author(s) 2023. published by oxford University press on behalf of american society for clinical pathology. all rights reserved. |
| Keywords: | acute lymphoblastic leukemia; t-cell lymphoma; transformation; t-all; clonal evolution; transdifferentiation; clonal hematopoiesis |
| Journal Title: | American Journal of Clinical Pathology |
| Volume: | 159 |
| Issue: | 6 |
| ISSN: | 0002-9173 |
| Publisher: | Oxford University Press |
| Date Published: | 2023-06-01 |
| Start Page: | 626 |
| End Page: | 637 |
| Language: | English |
| DOI: | 10.1093/ajcp/aqad045 |
| PUBMED: | 37167533 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Review -- Source: Scopus |
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