Mature T-cell and NK-cell lymphoma involvement of the central nervous system: A single center experience Journal Article
| Authors: | Ma, H.; Marchi, E.; O’Connor, O. A.; Lue, J. K. |
| Article Title: | Mature T-cell and NK-cell lymphoma involvement of the central nervous system: A single center experience |
| Abstract: | Mature T-cell and NK-cell lymphomas (MTNKL) are rare and heterogeneous lymphoproliferative disorders with poor clinical outcomes despite novel therapeutic advances. Although infrequent, central nervous system (CNS) involvement by MTNKL is associated with poor outcomes with a median overall survival (OS) of <12 months based on retrospective studies. We performed a retrospective analysis of patients who developed CNS involvement of MTNKL diagnosed at a single center from 1999 through 2020. Twenty-five patients were identified. Characteristics such as a diagnosis of adult T-cell leukemia/lymphoma, extranodal involvement, and poor performance status were associated with a higher risk of CNS involvement (p < 0.01). The median OS after diagnosis with CNS involvement was approximately 1 month (0.03–103.97 months). Patients exposed to novel therapeutics and/or clinical trial enrollment tolerated treatment without safety concerns and appeared to derive reasonable therapeutic benefit. Despite advances in the field, new therapeutic approaches are needed for patients with MTNKL with CNS involvement. © 2023 Informa UK Limited, trading as Taylor & Francis Group. |
| Keywords: | adult; clinical article; controlled study; middle aged; retrospective studies; overall survival; prednisone; doxorubicin; cancer combination chemotherapy; gemcitabine; primary central nervous system lymphoma; cytarabine; methotrexate; t lymphocyte; t-lymphocytes; etoposide; cohort analysis; bendamustine; cyclophosphamide; dexamethasone; vincristine; pathology; retrospective study; ifosfamide; central nervous system tumor; central nervous system; central nervous system neoplasms; lymphoma; asparaginase; bleomycin; outcomes research; stereotactic radiosurgery; oxaliplatin; romidepsin; pralatrexate; performance; azacitidine; neuroprotection; nk t cell lymphoma; anaplastic large cell lymphoma; asparaginase macrogol; brentuximab vedotin; humans; human; male; female; article; alk-positive anaplastic large cell lymphoma; adult t cell leukemia; mature t-cell and nk-cell lymphoma |
| Journal Title: | Leukemia and Lymphoma |
| Volume: | 64 |
| Issue: | 12 |
| ISSN: | 1042-8194 |
| Publisher: | Taylor & Francis Group |
| Date Published: | 2023-01-01 |
| Start Page: | 1964 |
| End Page: | 1970 |
| Language: | English |
| DOI: | 10.1080/10428194.2023.2245513 |
| PUBMED: | 37565580 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Source: Scopus |
