An ISCT Stem Cell Engineering Committee Position Statement on Immune Reconstitution: The importance of predictable and modifiable milestones of immune reconstitution to transplant outcomes Guidelines
| Authors: | Bertaina, A.; Abraham, A.; Bonfim, C.; Cohen, S.; Purtill, D.; Ruggeri, A.; Weiss, D.; Wynn, R.; Boelens, J. J.; Prockop, S.; on behalf of the ISCT Committee on Stem Cell Engineering |
| Title: | An ISCT Stem Cell Engineering Committee Position Statement on Immune Reconstitution: The importance of predictable and modifiable milestones of immune reconstitution to transplant outcomes |
| Abstract: | Allogeneic stem cell transplantation is a potentially curative therapy for some malignant and non-malignant disease. There have been substantial advances since the approaches first introduced in the 1970s, and the development of approaches to transplant with HLA incompatible or alternative donors has improved access to transplant for those without a fully matched donor. However, success is still limited by morbidity and mortality from toxicity and imperfect disease control. Here we review our emerging understanding of how reconstitution of effective immunity after allogeneic transplant can protect from these events and improve outcomes. We provide perspective on milestones of immune reconstitution that are easily measured and modifiable. © 2021 International Society for Cell & Gene Therapy |
| Keywords: | t cells; immune reconstitution; hematopoietic stem cell transplant |
| Journal Title: | Cytotherapy |
| Volume: | 24 |
| Issue: | 4 |
| ISSN: | 1465-3249 |
| Publisher: | Elsevier Science Ltd. |
| Date Published: | 2022-04-01 |
| Start Page: | 385 |
| End Page: | 392 |
| Language: | English |
| DOI: | 10.1016/j.jcyt.2021.09.011 |
| PROVIDER: | scopus |
| PUBMED: | 35331394 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 April 2022 -- Source: Scopus |
