Adoptive precursor cell therapy to enhance immune reconstitution after hematopoietic stem cell transplantation Journal Article

  

Authors:	Zakrzewski, J. L.; Holland, A. M.; van den Brink, M. R. M.
Article Title:	Adoptive precursor cell therapy to enhance immune reconstitution after hematopoietic stem cell transplantation
Abstract:	Strategies to enhance post-transplant immune reconstitution without aggravating graft-vs-host disease (GVHD) can improve the outcome of allogeneic hematopoietic stem cell transplantation. Recent preclinical studies demonstrated that the use of T cell depleted allografts supplemented with committed progenitor cells (vs stem cells only) allows enhanced immune reconstitution of specific hematopoietic lineages including myeloid, B, T, and natural killer lineages in the absence of GVHD. This novel adoptive therapy resulted in significantly improved resistance to microbial pathogens and could, in some cases, even mediate tumor immunity. Clinical protocols using adoptive transfer of committed hematopoietic progenitor cells are currently being evaluated. © 2007 Springer-Verlag.
Keywords:	treatment outcome; allograft; review; nonhuman; adjuvant therapy; t lymphocyte; stem cell factor; models, biological; granulocyte macrophage colony stimulating factor; interleukin 7; clinical protocol; hematopoietic stem cell transplantation; growth hormone; b lymphocyte; cell lineage; cell specificity; stem cell; cytokine; engraftment; kinetics; graft versus host reaction; allogeneic hematopoietic stem cell transplantation; cell therapy; natural killer cell; adoptive transfer; tumor immunity; thymidine kinase; hormonal therapy; bone marrow cell; hematopoietic stem cell; somatomedin c; gonadorelin agonist; hormone; flt3 ligand; t cell depletion; sex hormone; growth factor; granulocyte colony stimulating factor; herpes simplex virus; ganciclovir; adoptive immunotherapy; interleukin 15; keratinocyte growth factor; transplantation immunology; prolactin; immunity, cellular; adoptive cell transfer; infection resistance; immunodeficiency; suicide gene therapy; xenotransplantation; adoptive precursor cell therapy; common lymphoid progenitor cell; prolymphocyte
Journal Title:	Journal of Molecular Medicine
Volume:	85
Issue:	8
ISSN:	0946-2716
Publisher:	Springer
Date Published:	2007-08-01
Start Page:	837
End Page:	843
Language:	English
DOI:	10.1007/s00109-007-0175-4
PUBMED:	17333096
PROVIDER:	scopus
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-34447543921&partnerID=40&md5=9c9930a87932bff06a5971e68442f6f7
Notes:	--- - "Cited By (since 1996): 3" - "Export Date: 17 November 2011" - "CODEN: JMLME" - "Source: Scopus"

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