Enhancing T cell reconstitution after hematopoietic stem cell transplantation: A brief update of the latest trends Journal Article

   

Authors:	Zakrzewski, J. L.; Goldberg, G. L.; Smith, O. M.; van den Brink, M. R. M.
Article Title:	Enhancing T cell reconstitution after hematopoietic stem cell transplantation: A brief update of the latest trends
Abstract:	Hematopoietic stem cell transplantation (HSCT) is associated with a period of immune incompetence that particularly affects the T cell lineage. Strategies to enhance T cell reconstitution could significantly improve the survival of HSCT recipients by decreasing the incidence of fatal infectious complications and by enhancing graft-versus-tumor activity. In recent years, a variety of promising strategies have been established in preclinical models to improve T cell recovery in particular after allogeneic T cell-depleted HSCT, without aggravating graft-versus-host disease while preserving or even improving graft-versus-tumor activity. These therapies include treatment with keratinocyte growth factor (KGF), growth hormone (GH), LHRH agonists, interleukin 7 (IL-7) and interleukin 15 (IL-15). Thanks to the establishment of Notch-based culture systems, adoptive cellular therapies with T lineage-committed precursor cells have become feasible, since early T cell progenitors can now easily be generated in vitro in large quantities and have been proven to be very effective in enhancing T cell reconstitution and anti-tumor activity after allogeneic T cell-depleted HSCT. The translation of most of these strategies into clinical trials is likely and in some cases Phase I/II studies are already underway. © 2007 Elsevier Inc. All rights reserved.
Keywords:	intercellular signaling peptides and proteins; survival rate; clinical trial; t lymphocyte; t-lymphocytes; immune system; interleukin 7; notch receptor; hematopoietic stem cell transplantation; growth hormone; regeneration; hematologic malignancy; graft versus host reaction; hematopoietic stem cells; cell culture techniques; adoptive cell therapy; cell therapy; gonadorelin agonist; immune deficiency; t cell depletion; graft versus leukemia effect; interleukin 15; keratinocyte growth factor; infection complication; hormones; recipient; cytokine therapy; kgf; t cell deficiency
Journal Title:	Blood Cells, Molecules, and Diseases
Volume:	40
Issue:	1
ISSN:	1079-9796
Publisher:	Elsevier Inc.
Date Published:	2008-01-01
Start Page:	44
End Page:	47
Language:	English
DOI:	10.1016/j.bcmd.2007.07.015
PUBMED:	17905611
PROVIDER:	scopus
PMCID:	PMC2684110
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-36549064657&partnerID=40&md5=01ce8a158bd37ad595a1e8555c6d5216
Notes:	--- - "Cited By (since 1996): 8" - "Export Date: 17 November 2011" - "CODEN: BCMDF" - "Source: Scopus"

https://synapse.mskcc.org/synapse/works/has_related_data_chk/15656