Clinical strategies to enhance thymic recovery after allogeneic hematopoietic stem cell transplantation Journal Article

   


Authors: Velardi, E.; Dudakov, J. A.; van den Brink, M. R. M.
Article Title: Clinical strategies to enhance thymic recovery after allogeneic hematopoietic stem cell transplantation
Abstract: The thymus is particularly sensitive to injury caused by cytoreductive chemo- or radiation therapy, shock, infection and graft versus host disease. Insufficient thymic recovery has been directly correlated with increased risk of opportunistic infections and poor clinical outcomes in recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT). Prolonged immune deficiency is particularly pronounced in older patients whose thymi are already significantly impaired due to age-related thymic involution. Preclinical and clinical studies have revealed several strategies that can enhance thymic function and immune reconstitution after transplant, including sex steroid ablation, growth factors (growth hormone, keratinocyte growth factor, insulin-like growth factor 1, interleukin-7) and ex vivo generated precursor T cells. In addition, recent studies have shown that other approaches, such as interleukein-22 and nutritional changes, may represent additional candidates to enhance thymic regeneration. In this review we provide updates on these strategies and comment on their potential to be translated into clinical therapies. © 2013 Elsevier B.V.
Keywords: thymus; allogeneic hematopoietic stem cell transplantation; immune regeneration
Journal Title: Immunology Letters
Volume: 155
Issue: 1-2
ISSN: 0165-2478
Publisher: Elsevier Science, Inc.  
Date Published: 2013-09-01
Start Page: 31
End Page: 35
Language: English
DOI: 10.1016/j.imlet.2013.09.016
PROVIDER: scopus
PUBMED: 24120996
PMCID: PMC3871183
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84887817115&partnerID=40&md5=dac9c3e97805df16b8f9013ef9ea90dc
Notes: --- - "Export Date: 2 December 2013" - "CODEN: IMLED" - "Source: Scopus"
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MSK Authors
  1. Marcel R M Van Den Brink
    616 Van Den Brink
  2. Jarrod Andrew Dudakov
    58 Dudakov
  3. Enrico Velardi
    45 Velardi
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