Immune reconstitution after allogeneic hematopoietic stem cell transplantation: Time to T up the thymus Journal Article
| Authors: | Chaudhry, M. S.; Velardi, E.; Malard, F.; Van Den Brink, M. R. M. |
| Article Title: | Immune reconstitution after allogeneic hematopoietic stem cell transplantation: Time to T up the thymus |
| Abstract: | The success of allogeneic hematopoietic stem cell transplantation, a key treatment for many disorders, is intertwined with T cell immune reconstitution. The thymus plays a key role post allogeneic hematopoietic stem cell transplantation in the generation of a broad but self-tolerant T cell repertoire, but it is exquisitely sensitive to a range of insults during the transplant period, including conditioning regimens, corticosteroids, infections, and graft-versus-host disease. Although endogenous thymic repair is possible it is often suboptimal, and there is a need to develop exogenous strategies to help regenerate the thymus. Therapies currently in clinical trials in the transplant setting include keratinocyte growth factor, cytokines (IL-7 and IL-22), and hormonal modulation including sex steroid inhibition and growth hormone administration. Such regenerative strategies may ultimately enable the thymus to play as prominent a role after transplant as it once did in early childhood, allowing a more complete restoration of the T cell compartment. Copyright © 2016 by The American Association of Immunologists, Inc. |
| Journal Title: | Journal of Immunology |
| Volume: | 198 |
| Issue: | 1 |
| ISSN: | 0022-1767 |
| Publisher: | The American Association of Immunologists, Inc |
| Date Published: | 2017-01-01 |
| Start Page: | 40 |
| End Page: | 46 |
| Language: | English |
| DOI: | 10.4049/jimmunol.1601100 |
| PROVIDER: | scopus |
| PUBMED: | 27994167 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 2 February 2017 -- Source: Scopus |
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