T cell regeneration after immunological injury Review

   


Authors: Velardi, E.; Tsai, J. J.; van den Brink, M. R. M.
Review Title: T cell regeneration after immunological injury
Abstract: Following periods of haematopoietic cell stress, such as after chemotherapy, radiotherapy, infection and transplantation, patient outcomes are linked to the degree of immune reconstitution, specifically of T cells. Delayed or defective recovery of the T cell pool has significant clinical consequences, including prolonged immunosuppression, poor vaccine responses and increased risks of infections and malignancies. Thus, strategies that restore thymic function and enhance T cell reconstitution can provide considerable benefit to individuals whose immune system has been decimated in various settings. In this Review, we focus on the causes and consequences of impaired adaptive immunity and discuss therapeutic strategies that can recover immune function, with a particular emphasis on approaches that can promote a diverse repertoire of T cells through de novo T cell formation. © 2020, Springer Nature Limited.
Keywords: cancer chemotherapy; review; nonhuman; cancer radiotherapy; rituximab; t lymphocyte; stem cell factor; infection; interleukin 21; interleukin 7; hematopoietic stem cell transplantation; growth hormone; b lymphocyte; cellular immunity; pre t lymphocyte; graft versus host reaction; cell regeneration; somatomedin c; adaptive immunity; sex hormone; ghrelin; interleukin 12; interleukin 15; keratinocyte growth factor; graft recipient; thymus function; interleukin 22; osteoclast differentiation factor; immune reconstitution; cd135 antigen; thymosin alpha1; mesenchymal stroma cell; human; priority journal; immune injury; immunosenescence
Journal Title: Nature Reviews Immunology
Volume: 21
Issue: 5
ISSN: 1474-1733
Publisher: Nature Publishing Group  
Date Published: 2021-05-01
Start Page: 277
End Page: 291
Language: English
DOI: 10.1038/s41577-020-00457-z
PUBMED: 33097917
PROVIDER: scopus
PMCID: PMC7583557
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85093656945&doi=10.1038%2fs41577-020-00457-z&partnerID=40&md5=9af85e3d0fd7bba3e83715ad066671f8
Notes: Review -- Export Date: 1 June 2021 -- Source: Scopus
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Marcel R M Van Den Brink
    616 Van Den Brink
  2. Jennifer Tsai
    52 Tsai
Related MSK Work