Early recovery of T-cell function predicts improved survival after T-cell depleted allogeneic transplant Journal Article


Authors: Goldberg, J. D.; Zheng, J.; Ratan, R.; Small, T. N.; Lai, K. C.; Boulad, F.; Castro-Malaspina, H.; Giralt, S. A.; Jakubowski, A. A.; Kernan, N. A.; O’Reilly, R. J.; Papadopoulos, E. B.; Young, J. W.; van den Brink, M. R. M.; Heller, G.; Perales, M. A.
Article Title: Early recovery of T-cell function predicts improved survival after T-cell depleted allogeneic transplant
Abstract: Infection, relapse, and GVHD can complicate allogeneic hematopoietic stem cell transplantation (allo-HSCT). Although the effect of poor immune recovery on infection risk is well-established, there are limited data on the effect of immune reconstitution on relapse and survival, especially following T-cell depletion (TCD). To characterize the pattern of immune reconstitution in the first year after transplant and its effects on survival and relapse, we performed a retrospective study in 375 recipients of a myeloablative TCD allo-HSCT for hematologic malignancies. We noted that different subsets recover sequentially, CD8 + T cells first, followed by total CD4 + and naïve CD4 + T cells, indicating thymic recovery during the first year after HSCT. In the multivariate model, a fully HLA-matched donor and recovery of T-cell function, assessed by PHA response at 6 months, were the only factors independently associated with OS and EFS. In conclusion, T-cell recovery is an important predictor of outcome after TCD allo-HSCT. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Keywords: immune reconstitution; t-cell depletion; allogeneic hematopoietic stem cell transplant
Journal Title: Leukemia and Lymphoma
Volume: 58
Issue: 8
ISSN: 1042-8194
Publisher: Taylor & Francis Group  
Date Published: 2017-01-01
Start Page: 1859
End Page: 1871
Language: English
DOI: 10.1080/10428194.2016.1265113
PROVIDER: scopus
PUBMED: 28073320
PMCID: PMC5454777
DOI/URL:
Notes: Article -- Export Date: 4 April 2017 -- Source: Scopus
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MSK Authors
  1. Junting Zheng
    130 Zheng
  2. Nancy Kernan
    369 Kernan
  3. Trudy Small
    191 Small
  4. Farid Boulad
    245 Boulad
  5. Glenn Heller
    291 Heller
  6. Sergio Andres Giralt
    516 Giralt
  7. Miguel-Angel Perales
    365 Perales
  8. James W Young
    250 Young
  9. Richard O'Reilly
    468 O'Reilly
  10. Ravin Ratan
    6 Ratan
  11. Kuan-Chi Lai
    2 Lai