Synapse - Early recovery of T-cell function predicts improved survival after T-cell depleted allogeneic transplant

Early recovery of T-cell function predicts improved survival after T-cell depleted allogeneic transplant Journal Article

Authors:	Goldberg, J. D.; Zheng, J.; Ratan, R.; Small, T. N.; Lai, K. C.; Boulad, F.; Castro-Malaspina, H.; Giralt, S. A.; Jakubowski, A. A.; Kernan, N. A.; O’Reilly, R. J.; Papadopoulos, E. B.; Young, J. W.; van den Brink, M. R. M.; Heller, G.; Perales, M. A.
Article Title:	Early recovery of T-cell function predicts improved survival after T-cell depleted allogeneic transplant
Abstract:	Infection, relapse, and GVHD can complicate allogeneic hematopoietic stem cell transplantation (allo-HSCT). Although the effect of poor immune recovery on infection risk is well-established, there are limited data on the effect of immune reconstitution on relapse and survival, especially following T-cell depletion (TCD). To characterize the pattern of immune reconstitution in the first year after transplant and its effects on survival and relapse, we performed a retrospective study in 375 recipients of a myeloablative TCD allo-HSCT for hematologic malignancies. We noted that different subsets recover sequentially, CD8 + T cells first, followed by total CD4 + and naïve CD4 + T cells, indicating thymic recovery during the first year after HSCT. In the multivariate model, a fully HLA-matched donor and recovery of T-cell function, assessed by PHA response at 6 months, were the only factors independently associated with OS and EFS. In conclusion, T-cell recovery is an important predictor of outcome after TCD allo-HSCT. © 2016 Informa UK Limited, trading as Taylor & Francis Group.
Keywords:	immune reconstitution; t-cell depletion; allogeneic hematopoietic stem cell transplant
Journal Title:	Leukemia and Lymphoma
Volume:	58
Issue:	8
ISSN:	1042-8194
Publisher:	Taylor & Francis Group
Date Published:	2017-01-01
Start Page:	1859
End Page:	1871
Language:	English
DOI:	10.1080/10428194.2016.1265113
PROVIDER:	scopus
PUBMED:	28073320
PMCID:	PMC5454777
DOI/URL:	https://www.scopus.com/inward/record.uri?eid=2-s2.0-85009284477&doi=10.1080%2f10428194.2016.1265113&partnerID=40&md5=b52570327bc5592112bc7f386234adb7
Notes:	Article -- Export Date: 4 April 2017 -- Source: Scopus