Recombinant human interleukin-7 (CYT107) promotes T-cell recovery after allogeneic stem cell transplantation Journal Article

Authors: Perales, M. A.; Goldberg, J. D.; Yuan, J.; Koehne, G.; Lechner, L.; Papadopoulos, E. B.; Young, J. W.; Jakubowski, A. A.; Zaidi, B.; Gallardo, H.; Liu, C.; Rasalan, T.; Wolchok, J. D.; Croughs, T.; Morre, M.; Devlin, S. M.; van den Brink, M. R. M.
Article Title: Recombinant human interleukin-7 (CYT107) promotes T-cell recovery after allogeneic stem cell transplantation
Abstract: Delays in immune recovery after allogeneic hematopoietic stem cell transplantation (allo-HSCT) are associated with increased risks of infection and relapse. IL-7 has a central role in T-cell development and survival and enhances immune recovery in murine models of allo-HSCT. We performed a phase 1 trial of r-hIL-7 (CYT107) in recipients of T-cell depleted allo-HSCTs. Twelve patients were treated with escalating doses of r-hIL-7 administered weekly for 3 weeks. The study drug was well tolerated with only one patient developing acute skin GVHD. At baseline, patients were profoundly lymphopenic. CYT107 induced a doubling in CD4+ and CD8+ T cells. The main effect of IL-7 was an expansion of effector memory T cells, the predominant subset identified in our patients. There was no significant effect on CD4+CD25 +FoxP3+ T cells, NK, or B cells. Importantly, we not only saw quantitative increases in T cells after a short course of IL-7 but also demonstrated an increase in functional T cells, including viral-specific T cells that recognize CMV. Enhanced TCR diversity was also observed after treatment. Our results indicate that r-hIL-7 can enhance immune recovery after a T cell-depleted allo-HSCT without causing significant GVHD or other serious toxicity (; NCT00684008). © 2012 by The American Society of Hematology.
Journal Title: Blood
Volume: 120
Issue: 24
ISSN: 0006-4971
Publisher: American Society of Hematology  
Date Published: 2012-12-06
Start Page: 4882
End Page: 4891
Language: English
DOI: 10.1182/blood-2012-06-437236
PROVIDER: scopus
PUBMED: 23012326
PMCID: PMC3520625
Notes: --- - "Cited By (since 1996): 1" - "Export Date: 2 January 2013" - "CODEN: BLOOA" - "Source: Scopus"
Citation Impact
MSK Authors
  1. Jedd D Wolchok
    813 Wolchok
  2. Miguel-Angel Perales
    584 Perales
  3. Guenther Koehne
    194 Koehne
  4. James W Young
    297 Young
  5. Cailian Liu
    51 Liu
  6. Jianda Yuan
    105 Yuan
  7. Teresa Rasalan
    28 Rasalan
  8. Bushra Zaidi
    12 Zaidi
  9. Sean McCarthy Devlin
    442 Devlin