Synapse - Recombinant human interleukin-7 (CYT107) promotes T-cell recovery after allogeneic stem cell transplantation

Recombinant human interleukin-7 (CYT107) promotes T-cell recovery after allogeneic stem cell transplantation Journal Article

Authors:	Perales, M. A.; Goldberg, J. D.; Yuan, J.; Koehne, G.; Lechner, L.; Papadopoulos, E. B.; Young, J. W.; Jakubowski, A. A.; Zaidi, B.; Gallardo, H.; Liu, C.; Rasalan, T.; Wolchok, J. D.; Croughs, T.; Morre, M.; Devlin, S. M.; van den Brink, M. R. M.
Article Title:	Recombinant human interleukin-7 (CYT107) promotes T-cell recovery after allogeneic stem cell transplantation
Abstract:	Delays in immune recovery after allogeneic hematopoietic stem cell transplantation (allo-HSCT) are associated with increased risks of infection and relapse. IL-7 has a central role in T-cell development and survival and enhances immune recovery in murine models of allo-HSCT. We performed a phase 1 trial of r-hIL-7 (CYT107) in recipients of T-cell depleted allo-HSCTs. Twelve patients were treated with escalating doses of r-hIL-7 administered weekly for 3 weeks. The study drug was well tolerated with only one patient developing acute skin GVHD. At baseline, patients were profoundly lymphopenic. CYT107 induced a doubling in CD4+ and CD8+ T cells. The main effect of IL-7 was an expansion of effector memory T cells, the predominant subset identified in our patients. There was no significant effect on CD4+CD25 +FoxP3+ T cells, NK, or B cells. Importantly, we not only saw quantitative increases in T cells after a short course of IL-7 but also demonstrated an increase in functional T cells, including viral-specific T cells that recognize CMV. Enhanced TCR diversity was also observed after treatment. Our results indicate that r-hIL-7 can enhance immune recovery after a T cell-depleted allo-HSCT without causing significant GVHD or other serious toxicity (www.clinicaltrials.gov; NCT00684008). © 2012 by The American Society of Hematology.
Journal Title:	Blood
Volume:	120
Issue:	24
ISSN:	0006-4971
Publisher:	American Society of Hematology
Date Published:	2012-12-06
Start Page:	4882
End Page:	4891
Language:	English
DOI:	10.1182/blood-2012-06-437236
PROVIDER:	scopus
PUBMED:	23012326
PMCID:	PMC3520625
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-84870727272&partnerID=40&md5=30fdc124d498e9efbbd5892c1cd6dfbf
Notes:	--- - "Cited By (since 1996): 1" - "Export Date: 2 January 2013" - "CODEN: BLOOA" - "Source: Scopus"