Immune reconstitution after cord blood transplantation: Peculiarities, clinical implications and management strategies Journal Article


Authors: Lucchini, G.; Perales, M. A.; Veys, P.
Article Title: Immune reconstitution after cord blood transplantation: Peculiarities, clinical implications and management strategies
Abstract: Umbilical cord blood (UCB) is now widely used as an alternative hematopoietic stem cell source for patients lacking closely matched related or unrelated adult donors. UCB transplantation has traditionally been associated with delayed engraftment, poor immune reconstitution and consequent increased risk of infection. More recent clinical studies, however, suggest that conditioning regimens and in particular the omission of invivo T-cell depletion may play a crucial role in post-transplant T-cell expansion, facilitating a uniquely rapid immune recovery after UCB transplantation. The peculiar characteristics of UCB cells, the importance of thymic function and the role of conditioning regimens and graft-versus-host disease influencing immune reconstitution are described. The last part of the review reports available data on UCB, as well as third-party peripheral blood derived anti-viral cell therapy, which provides a novel approach to rescue UCB recipients with viral complications in the post-transplant period. © 2015 International Society for Cellular Therapy.
Keywords: treatment response; postoperative period; t cells; stem cell transplantation; in vivo study; high risk patient; b lymphocyte; cytokine; cord blood stem cell transplantation; engraftment; immune response; cytotoxic t lymphocyte; graft versus host reaction; natural killer cell; umbilical cord blood; immunomodulation; therapy effect; virus infection; clinical effectiveness; t cell depletion; immunosuppressive treatment; cyclosporin; infection risk; immunopathology; thymus function; cell homing; stem cell expansion; viral infections; mycophenolate mofetil; thymic function; human; priority journal; article; serotherapy; immune-reconstitution
Journal Title: Cytotherapy
Volume: 17
Issue: 6
ISSN: 1465-3249
Publisher: Elsevier Science Ltd.  
Date Published: 2015-06-01
Start Page: 711
End Page: 722
Language: English
DOI: 10.1016/j.jcyt.2015.03.614
PROVIDER: scopus
PUBMED: 25946726
DOI/URL:
Notes: Export Date: 3 June 2015 -- Source: Scopus
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MSK Authors
  1. Miguel-Angel Perales
    378 Perales