Immune reconstitution following hematopoietic cell transplantation Book Section

Authors: Dudakov, J. A.; Perales, M. A.; van den Brink, M. R. M.
Editors: Forman, S. J.; Negrin, R. S.; Antin, J. H.; Appelbaum, F. R.
Article/Chapter Title: Immune reconstitution following hematopoietic cell transplantation
Abstract: Hematopoietic cell transplantation (HCT) is complicated by post-transplant immune deficiency, which is more profound after allogeneic than autologous HCT. Cytoreductive conditioning regimens eliminate tumor cells and significantly deplete the recipient's immune system, in particular cells of the lymphoid lineageand allow for successful engraftment of hematopoietic stem cells (HSCs) in their bone marrow niche. This chapter reviews immune reconstitution following HCT, with a particular emphasis on factors that contribute to delayed immune recovery post-transplant and the clinical consequences. It also discusses current clinical and research assays to monitor post-HCT immune recovery and highlights some of the potential strategies that are currently under investigation to enhance immune recovery in HCT recipients. Post-transplant immune deficiency is due to a variety of factors, including age-dependent thymic involution, conditioning-induced thymic damage, thymic GVHD, GVHD prophylaxis including in vivo or ex vivo T cell depletion, and treatment with immune-suppressive drugs. © 2016 John Wiley & Sons, Ltd. All rights reserved.
Keywords: immune reconstitution; hematopoietic cell transplantation; immune regeneration; gvhd prophylaxis; post-transplant immune deficiency; prolonged immune depletion; t-cell recovery
Book Title: Thomas’ Hematopoietic Cell Transplantation: Stem Cell Transplantation. 5th ed
Volume: 1
ISBN: 978-1-118-41600-6
Publisher: Wiley Blackwell  
Publication Place: Chichester, UK
Date Published: 2016-01-01
Start Page: 160
End Page: 169
Language: English
DOI: 10.1002/9781118416426.ch15
PROVIDER: scopus
Notes: Book Chapter: 15 -- Export Date: 1 September 2016 -- Source: Scopus
Citation Impact
MSK Authors
  1. Miguel-Angel Perales
    465 Perales
  2. Jarrod Andrew Dudakov
    58 Dudakov