Strategies to enhance T-cell reconstitution in immunocompromised patients Journal Article

  


Authors: van den Brink, M. R. M.; Alpdogan, O.; Boyd, R. L.
Article Title: Strategies to enhance T-cell reconstitution in immunocompromised patients
Abstract: Immune deficiency, together with its associated risks such as infections, is becoming an increasingly important clinical problem owing to the ageing of the general population and the increasing number of patients with HIV/AIDS, malignancies (especially those treated with intensive chemotherapy or radiotherapy) or transplants (of either solid organs or haematopoietic stem cells). Of all immune cells, T cells are the most often affected, leading to a prolonged deficiency of T cells, which has important clinical consequences. Accordingly, strategies to improve the recovery and function of T cells, as we discuss here, should have a direct impact on reducing the morbidity and mortality of many patients and should increase the efficacy of therapeutic and prophylactic vaccinations against microbial pathogens or tumours.
Keywords: cancer chemotherapy; human cell; review; nonhuman; cancer patient; cancer radiotherapy; human immunodeficiency virus infection; cd8 antigen; t lymphocyte; t-lymphocytes; animal cell; mouse; animals; mice; interleukin 2; bone marrow; spleen; interleukin 7; animal model; stem cell transplantation; t lymphocyte receptor; cytokine; cytokines; thymus; thymus gland; lymph node; allogeneic hematopoietic stem cell transplantation; adoptive transfer; acquired immune deficiency syndrome; somatomedin c; cd4 antigen; gonadorelin derivative; hormone; lymphoid tissue; sex hormone; lymphopoiesis; growth factor; interleukin 12; interleukin 15; keratinocyte growth factor; cd28 antigen; hormones; growth substances; organ transplantation; immune system diseases; humans; human; priority journal; oncostatin m
Journal Title: Nature Reviews Immunology
Volume: 4
Issue: 11
ISSN: 1474-1733
Publisher: Nature Publishing Group  
Date Published: 2004-11-01
Start Page: 856
End Page: 867
Language: English
DOI: 10.1038/nri1484
PROVIDER: scopus
PUBMED: 15516965
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-8544266027&partnerID=40&md5=5784582ba16c98286c5bac1f048f8a9d
Notes: Nat. Rev. Immunol. -- Cited By (since 1996):95 -- Export Date: 16 June 2014 -- CODEN: NRIAB -- Source: Scopus
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MSK Authors
  1. Marcel R M Van Den Brink
    616 Van Den Brink
  2. Seyfettin O Alpdogan
    75 Alpdogan
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