Severe and selective deficiency of interferon-γ-producing invariant natural killer T cells in patients with myelodysplastic syndromes Journal Article

  


Authors: Fujii, S. I.; Shimizu, K.; Klimek, V.; Geller, M. D.; Nimer, S. D.; Dhodapkar, M. V.
Article Title: Severe and selective deficiency of interferon-γ-producing invariant natural killer T cells in patients with myelodysplastic syndromes
Abstract: Here we show that patients with myelodysplastic syndromes (MDS) have a severe deficiency of glycolipid reactive Vα24+/Vβ11 + natural killer T (NKT) cells, but not NK cells or CD4+ or CD8+ T cells. Neither the blood nor marrow of MDS patients had detectable interferon-γ-producing NKT cells in response to the NKT ligand, α-galactosyl ceramide, although influenza-virus-specific effector T-cell function was preserved. This severe and selective deficiency of an important immune regulatory cell may contribute to the pathogenesis of MDS.
Keywords: adult; clinical article; controlled study; aged; aged, 80 and over; middle aged; human cell; prednisone; flow cytometry; t lymphocyte; cd8-positive t-lymphocytes; bone marrow cells; erythropoietin; cell population; immunoregulation; t lymphocyte receptor; antigen presentation; myelodysplastic syndrome; mononuclear cell; gamma interferon; antigen specificity; blood sampling; cd4-positive t-lymphocytes; natural killer cell; killer cells, natural; effector cell; innate immunity; cell count; 5 aza 2' deoxycytidine; bone marrow cell; leukocyte count; t-lymphocyte subsets; granulocyte colony stimulating factor; lymphocyte count; receptors, antigen, t-cell, alpha-beta; myelodysplastic syndromes; lymphocyte function; natural killer t cell; immunity, cellular; galactosylceramide; glycolipids; natural killer t cells; interferon type ii; cd1d; humans; human; male; female; priority journal; article
Journal Title: British Journal of Haematology
Volume: 122
Issue: 4
ISSN: 0007-1048
Publisher: John Wiley & Sons  
Date Published: 2003-08-01
Start Page: 617
End Page: 622
Language: English
DOI: 10.1046/j.1365-2141.2003.04465.x
PUBMED: 12899717
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-0043163751&partnerID=40&md5=39bcc5d7fbb92c0104ffef77527ce016
Notes: Export Date: 12 September 2014 -- Source: Scopus
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MSK Authors
  1. Madhav Dhodapkar
    43 Dhodapkar
  2. Virginia Klimek
    147 Klimek
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