Clinical strategies to enhance T cell reconstitution Journal Article

   


Authors: Goldberg, G. L.; Zakrzewski, J. L.; Perales, M. A.; van den Brink, M. R. M.
Article Title: Clinical strategies to enhance T cell reconstitution
Abstract: Strategies to enhance T cell recovery are of increasing clinical importance to overcome long lasting T cell deficiencies, which occur in association with infections, autoimmunity and chemo/radiotherapy as well as aging of the immune system. In this review we discuss those strategies that are close to or in the clinic. Interleukin-7, sex steroid modulation, keratinocyte growth factor, growth hormone and cellular therapies using ex vivo generated T-cell precursors are currently being tested in recipients of a hematopoietic stem cell transplantation and patients with malignancies or HIV/AIDS. © 2007 Elsevier Ltd. All rights reserved.
Keywords: protein expression; unclassified drug; clinical trial; review; nonhuman; unspecified side effect; drug approval; human immunodeficiency virus infection; protein function; t-lymphocytes; mucosa inflammation; interleukin 7; estrogen; cyclophosphamide; dexamethasone; hematopoietic stem cell transplantation; food and drug administration; growth hormone; drug dose escalation; leuprorelin; drug mechanism; graft versus host reaction; hematopoietic stem cells; single drug dose; cell therapy; androgen receptor; acquired immune deficiency syndrome; somatomedin c; gonadorelin agonist; immune deficiency; bone marrow transplantation; sex hormone; thymus atrophy; testosterone; thymocyte; combined immunodeficiency; t lymphocyte activation; keratinocyte growth factor; recombinant interleukin 7; fibroblast growth factor 7; gonadal steroid hormones; repeated drug dose; interleukin-7; progesterone; interleukin 7 receptor; op9-dl1; sex steroid modulation; t cell reconstitution; cyt 107; cyt 99007
Journal Title: Seminars in Immunology
Volume: 19
Issue: 5
ISSN: 1044-5323
Publisher: Academic Press Inc., Elsevier Science  
Date Published: 2007-10-01
Start Page: 289
End Page: 296
Language: English
DOI: 10.1016/j.smim.2007.08.001
PUBMED: 17964803
PROVIDER: scopus
PMCID: PMC2696308
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-36549025327&partnerID=40&md5=923bdf1b7b2a3bd4381e9386dc9a0289
Notes: --- - "Cited By (since 1996): 31" - "Export Date: 17 November 2011" - "CODEN: SEIME" - "Source: Scopus"
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MSK Authors
  1. Marcel R M Van Den Brink
    618 Van Den Brink
  2. Gabrielle Lianne Goldberg
    24 Goldberg
  3. Miguel-Angel Perales
    938 Perales
  4. Johannes Lothar Zakrzewski
    57 Zakrzewski
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