Rejuvenation of the aging T cell compartment Journal Article

   


Authors: Holland, A. M.; Van Den Brink, M. R.
Article Title: Rejuvenation of the aging T cell compartment
Abstract: The elderly face significant risk for susceptibility to infection and cancer because of declining immune function. Various agents used in the setting of bone marrow transplantation and aging studies represent promising approaches to combating T cell defects in the aging population. Preclinical and clinical studies on the T cell reconstitution effects of sex steroid ablation, keratinocyte growth factor, the growth hormone pathway, and the cytokines interleukin-7, interleukin-12, and interleukin-15 indicate that these strategies may be used to alleviate the effects of T cell deficiencies in the elderly. © 2009 Elsevier Ltd. All rights reserved.
Keywords: signal transduction; clinical trial; review; nonhuman; t lymphocyte; t-lymphocytes; animals; mice; cancer susceptibility; melanoma; mucosa inflammation; inflammation; hematopoietic stem cell transplantation; growth hormone; sarcoma; goserelin; leuprorelin; cytokines; immune tolerance; cellular immunity; immune response; drug mechanism; cytokine production; aging; immunostimulation; cell regeneration; high risk population; somatomedin c; castration; bone marrow transplantation; sex hormone; insulin-like growth factor i; elderly care; cell expansion; rejuvenation; ghrelin; interleukin 12; interleukin 15; keratinocyte growth factor; recombinant interleukin 7; graft recipient; immunocompetent cell; immunopathology; infection sensitivity; lymphocytopoiesis; thymus function; fibroblast growth factor 7; gonadal steroid hormones; guided tissue regeneration
Journal Title: Current Opinion in Immunology
Volume: 21
Issue: 4
ISSN: 0952-7915
Publisher: Elsevier Inc.  
Date Published: 2009-08-01
Start Page: 454
End Page: 459
Language: English
DOI: 10.1016/j.coi.2009.06.002
PUBMED: 19608394
PROVIDER: scopus
PMCID: PMC2731988
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-68149148867&partnerID=40&md5=e2b8f52d46c89becd3651b34693f4944
Notes: --- - "Cited By (since 1996): 8" - "Export Date: 30 November 2010" - "CODEN: COPIE" - "Source: Scopus"
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MSK Authors
  1. Marcel R M Van Den Brink
    618 Van Den Brink
  2. Amanda M Holland
    55 Holland
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