Thymic involution and immune reconstitution Journal Article

   


Authors: Lynch, H. E.; Goldberg, G. L.; Chidgey, A.; van den Brink, M. R. M.; Boyd, R.; Sempowski, G. D.
Article Title: Thymic involution and immune reconstitution
Abstract: Chronic thymus involution associated with aging results in less efficient T-cell development and decreased emigration of naïve T cells to the periphery. Thymic decline in the aged is linked to increased morbidity and mortality in a wide range of clinical settings. Negative consequences of these effects on global health make it of paramount importance to understand the mechanisms driving thymic involution and homeostatic processes across the lifespan. There is growing evidence that thymus tissue is plastic and that the involution process might be therapeutically halted or reversed. We present here progress on the exploitation of thymosuppressive and thymostimulatory pathways using factors such as keratinocyte growth factor, interleukin 7 or sex steroid ablation for therapeutic thymus restoration and peripheral immune reconstitution in adults. © 2009 Elsevier Ltd. All rights reserved.
Keywords: mortality; review; nonhuman; pathophysiology; t lymphocyte; animals; cell maturation; mucosa inflammation; morbidity; interleukin 7; cyclophosphamide; dexamethasone; growth hormone; cytokines; immune response; drug mechanism; thymus gland; cell migration; aging; t-lymphocyte subsets; gonadorelin agonist; castration; homeostasis; sex hormone; thymus atrophy; involution; thymocyte; rejuvenation; ghrelin; keratinocyte growth factor; fibroblast growth factor 7; gonadal steroid hormones; gonadorelin antagonist; lifespan; oral mucositis; interleukin-7
Journal Title: Trends in Immunology
Volume: 30
Issue: 7
ISSN: 1471-4906
Publisher: Elsevier Inc.  
Date Published: 2009-07-01
Start Page: 366
End Page: 373
Language: English
DOI: 10.1016/j.it.2009.04.003
PUBMED: 19540807
PROVIDER: scopus
PMCID: PMC2750859
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-67649396090&partnerID=40&md5=cc5eae93eec40079b097a9003a7032ae
Notes: --- - "Cited By (since 1996): 15" - "Export Date: 30 November 2010" - "CODEN: TIRMA" - "Source: Scopus"
Altmetric
What is Altmetric?
Citation Impact
What is Dimensions Citation Badge?
BMJ Impact Analytics
MSK Authors
  1. Marcel R M Van Den Brink
    616 Van Den Brink
  2. Gabrielle Lianne Goldberg
    24 Goldberg
Related MSK Work