Interleukin-15 enhances immune reconstitution after allogeneic bone marrow transplantation Journal Article

Authors: Alpdogan, O.; Eng, J. M.; Muriglan, S. J.; Willis, L. M.; Hubbard, V. M.; Tjoe, K. H.; Terwey, T. H.; Kochman, A.; van den Brink, M. R. M.
Article Title: Interleukin-15 enhances immune reconstitution after allogeneic bone marrow transplantation
Abstract: Interleukin-15 (IL-15) is a γ-common cytokine that plays an important role in the development, survival, and proliferation of natural killer (NK), NK T, and CDS+ T-cells. We administered IL-15 to recipients of an allogeneic bone marrow transplantation (allo BMT) to determine its effects on immune reconstitution. Posttransplantation IL-15 administration significantly increased donor-derived CD8+ T (mostly CD122+CD44 +CD8+ T-cells), NK, and NK T-cells at day +28 in young and old recipients of allo BMT. This was associated with enhanced T-cell and NK-cell function. IL-15 stimulated homeostatic proliferation of donor CD8 + T-cells in recipients of carboxyfluorescein diacetate succinimidyl ester-labeled donor T-cell infusions. Posttransplantation IL-15 administration also resulted in a decrease in apoptotic CD8+ T-cells, an increase in Bcl-2-expressing CD8+ T-cells, and an increase in the fraction of Ki67+ proliferate NK and CD8+ T-cells in recipients of allo BMT. IL-15 did not exacerbate graft-versus-host disease (GVHD) in recipients of T-cell-depleted BMT but could aggravate GVHD in some cases in recipients of a T-celf-repleted BMT. Finally, we found that IL-15 administration could enhance graft-versus-leukemia activity. In conclusion, IL-15 can be administered safely to recipients of a T-cell-depleted allo BMT to enhance CD8+ T, NK, and NK T-cell reconstitution. © 2005 by The American Society of Hematology.
Keywords: controlled study; protein expression; recovery of function; transplantation, homologous; drug safety; nonhuman; cd8 antigen; ki 67 antigen; lymphocyte proliferation; t lymphocyte; cd8-positive t-lymphocytes; animal cell; mouse; animals; mice; cell survival; cell division; protein bcl 2; apoptosis; spleen; animal experiment; animal model; allogenic bone marrow transplantation; mice, inbred c57bl; cytokine; donor; thymus gland; graft versus host reaction; natural killer cell; killer cells, natural; homeostasis; bone marrow transplantation; graft vs host disease; disease exacerbation; graft versus leukemia effect; interleukin 15; immunologic memory; mice, inbred c3h; recipient; receptors, interleukin-2; interleukin-15; graft vs leukemia effect; antigens, cd44; carboxyfluorescein diacetate succinimidyl ester
Journal Title: Blood
Volume: 105
Issue: 2
ISSN: 0006-4971
Publisher: American Society of Hematology  
Date Published: 2005-01-15
Start Page: 865
End Page: 873
Language: English
DOI: 10.1182/blood-2003-09-3344
PUBMED: 15280205
PROVIDER: scopus
Notes: --- - "Cited By (since 1996): 69" - "Export Date: 24 October 2012" - "CODEN: BLOOA" - "Source: Scopus"
Citation Impact
MSK Authors
  1. Theis Helge Terwey
    18 Terwey
  2. Adam Kochman
    45 Kochman
  3. Vanessa Marie Hubbard
    42 Hubbard
  4. Lucy Willis
    28 Willis
  5. Jeffrey Eng
    36 Eng
  6. Kartono H Tjoe
    10 Tjoe