Interleukin-15 enhances immune reconstitution after allogeneic bone marrow transplantation Journal Article
| Authors: | Alpdogan, O.; Eng, J. M.; Muriglan, S. J.; Willis, L. M.; Hubbard, V. M.; Tjoe, K. H.; Terwey, T. H.; Kochman, A.; van den Brink, M. R. M. |
| Article Title: | Interleukin-15 enhances immune reconstitution after allogeneic bone marrow transplantation |
| Abstract: | Interleukin-15 (IL-15) is a γ-common cytokine that plays an important role in the development, survival, and proliferation of natural killer (NK), NK T, and CDS+ T-cells. We administered IL-15 to recipients of an allogeneic bone marrow transplantation (allo BMT) to determine its effects on immune reconstitution. Posttransplantation IL-15 administration significantly increased donor-derived CD8+ T (mostly CD122+CD44 +CD8+ T-cells), NK, and NK T-cells at day +28 in young and old recipients of allo BMT. This was associated with enhanced T-cell and NK-cell function. IL-15 stimulated homeostatic proliferation of donor CD8 + T-cells in recipients of carboxyfluorescein diacetate succinimidyl ester-labeled donor T-cell infusions. Posttransplantation IL-15 administration also resulted in a decrease in apoptotic CD8+ T-cells, an increase in Bcl-2-expressing CD8+ T-cells, and an increase in the fraction of Ki67+ proliferate NK and CD8+ T-cells in recipients of allo BMT. IL-15 did not exacerbate graft-versus-host disease (GVHD) in recipients of T-cell-depleted BMT but could aggravate GVHD in some cases in recipients of a T-celf-repleted BMT. Finally, we found that IL-15 administration could enhance graft-versus-leukemia activity. In conclusion, IL-15 can be administered safely to recipients of a T-cell-depleted allo BMT to enhance CD8+ T, NK, and NK T-cell reconstitution. © 2005 by The American Society of Hematology. |
| Keywords: | controlled study; protein expression; recovery of function; transplantation, homologous; drug safety; nonhuman; cd8 antigen; ki 67 antigen; lymphocyte proliferation; t lymphocyte; cd8-positive t-lymphocytes; animal cell; mouse; animals; mice; cell survival; cell division; protein bcl 2; apoptosis; spleen; animal experiment; animal model; allogenic bone marrow transplantation; mice, inbred c57bl; cytokine; donor; thymus gland; graft versus host reaction; natural killer cell; killer cells, natural; homeostasis; bone marrow transplantation; graft vs host disease; disease exacerbation; graft versus leukemia effect; interleukin 15; immunologic memory; mice, inbred c3h; recipient; receptors, interleukin-2; interleukin-15; graft vs leukemia effect; antigens, cd44; carboxyfluorescein diacetate succinimidyl ester |
| Journal Title: | Blood |
| Volume: | 105 |
| Issue: | 2 |
| ISSN: | 0006-4971 |
| Publisher: | American Society of Hematology |
| Date Published: | 2005-01-15 |
| Start Page: | 865 |
| End Page: | 873 |
| Language: | English |
| DOI: | 10.1182/blood-2003-09-3344 |
| PUBMED: | 15280205 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 69" - "Export Date: 24 October 2012" - "CODEN: BLOOA" - "Source: Scopus" |
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