Reconstitution of adaptive and innate immunity following allogeneic hematopoietic stem cell transplantation in humans Journal Article
| Author: | Peggs, K. S. |
| Article Title: | Reconstitution of adaptive and innate immunity following allogeneic hematopoietic stem cell transplantation in humans |
| Abstract: | Allogeneic hematopoietic stem cell transplantation is a potentially curative treatment modality for a number of hematologic malignancies, as well as inherited immunodeficiencies and hemoglobinopathies, and may also have a role in selected acquired autoimmune disorders. The complete or near-complete ablation of host immunity and subsequent establishment of donor-derived immunity that is required for successful engraftment and long-term outcomes provide a major obstacle to such transplantation approaches. A delicate balance exists between the need for the reconstituted donor-derived immunity to provide both protection against pathogenic challenges and graft-versus-malignancy activity, and the potentially harmful expansion of alloreactive T-cell clones mediating GvHD. The search for interventions that would allow more rapid and selective reconstitution of beneficial immune specificities continues to be informed by the development of new tools enabling a more precise dissection of the kinetics of reconstituting populations. This review summarizes more recent data on immune reconstitution following allogeneic transplantation in humans. |
| Keywords: | recovery of function; transplantation, homologous; unclassified drug; clinical trial; review; nonhuman; alpha interferon; cd8 antigen; cd8+ t lymphocyte; t lymphocyte; mesenchyme cell; interleukin 2; granulocyte macrophage colony stimulating factor; interleukin 7; hematopoietic stem cell transplantation; transplantation; b lymphocyte; monoclonal antibody; t lymphocyte receptor; cd4+ cd25+ t lymphocyte; regulatory t lymphocyte; hematologic malignancy; hematologic neoplasms; tissue donors; cpg oligodeoxynucleotide; cd4+ t lymphocyte; graft versus host reaction; stem cell mobilization; outcomes research; allogeneic hematopoietic stem cell transplantation; natural killer cell; innate immunity; immunity, innate; hormonal therapy; cd4 antigen; immune deficiency; flt3 ligand; autoimmune disease; graft vs host disease; stroma cell; peripheral blood stem cell transplantation; granulocyte colony stimulating factor; disease exacerbation; graft versus leukemia effect; adoptive immunotherapy; antigen presenting cell; lymphocyte depletion; interleukin 12; interleukin 15; keratinocyte growth factor; cd45 antigen; transplantation chimera; drug delivery system; host pathogen interaction; interleukin 2 receptor alpha; interleukin 18; alloimmunity; immune reconstitution; cell cloning; hemoglobinopathy; heat shock protein; adaptive; innate; immunity, natural; cd20 antibody; cd4 cd8 ratio; cd45rb antigen |
| Journal Title: | Cytotherapy |
| Volume: | 8 |
| Issue: | 5 |
| ISSN: | 1465-3249 |
| Publisher: | Elsevier Science Ltd. |
| Date Published: | 2006-11-01 |
| Start Page: | 427 |
| End Page: | 436 |
| Language: | English |
| DOI: | 10.1080/14653240600851938 |
| PUBMED: | 17050247 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 11" - "Export Date: 4 June 2012" - "CODEN: CYTRF" - "Source: Scopus" |
